Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia

John A. Sweeley, Gretchen L. Haas, Shuhua Li, Peter J. Weiden

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The potential impact of antipsychotic medications on eye-tracking impairments in schizophrenia has received little systematic attention. To address this issue, eye-tracking performance was studied in 19 neuroliptic-naive schizophrenic patients, 22 previously medicated schizophrenic patients who had not received antipsychotic drugs for at least 28 days, and 52 nonpsychiatric control subjects. Impairments were similar but generally more severe in previously treated than in neuroleptic-naive patients. An attention-facilitation manipulation improved eye-tracking performance in all groups. Ten neuroleptic-naive and 14 previously treated cases were retested after at least 3 weeks of treatment with antipsychotic medication. Short-term treatment with neuroleptics improved certain attention-related aspects of eye tracking involving saccadic eye movements such as anticipatory saccades, but it did not alter pursuit eye movements.

Original languageEnglish (US)
Pages (from-to)185-198
Number of pages14
JournalPsychiatry Research
Volume54
Issue number2
DOIs
StatePublished - 1994

Fingerprint

Antipsychotic Agents
Schizophrenia
Saccades
Eye Movements
Therapeutics

Keywords

  • attention
  • eye movements
  • Neuroleptic medication
  • oculomotor activity
  • saccades

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia. / Sweeley, John A.; Haas, Gretchen L.; Li, Shuhua; Weiden, Peter J.

In: Psychiatry Research, Vol. 54, No. 2, 1994, p. 185-198.

Research output: Contribution to journalArticle

Sweeley, John A. ; Haas, Gretchen L. ; Li, Shuhua ; Weiden, Peter J. / Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia. In: Psychiatry Research. 1994 ; Vol. 54, No. 2. pp. 185-198.
@article{663c9b06b216440fa88bf120b895d252,
title = "Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia",
abstract = "The potential impact of antipsychotic medications on eye-tracking impairments in schizophrenia has received little systematic attention. To address this issue, eye-tracking performance was studied in 19 neuroliptic-naive schizophrenic patients, 22 previously medicated schizophrenic patients who had not received antipsychotic drugs for at least 28 days, and 52 nonpsychiatric control subjects. Impairments were similar but generally more severe in previously treated than in neuroleptic-naive patients. An attention-facilitation manipulation improved eye-tracking performance in all groups. Ten neuroleptic-naive and 14 previously treated cases were retested after at least 3 weeks of treatment with antipsychotic medication. Short-term treatment with neuroleptics improved certain attention-related aspects of eye tracking involving saccadic eye movements such as anticipatory saccades, but it did not alter pursuit eye movements.",
keywords = "attention, eye movements, Neuroleptic medication, oculomotor activity, saccades",
author = "Sweeley, {John A.} and Haas, {Gretchen L.} and Shuhua Li and Weiden, {Peter J.}",
year = "1994",
doi = "10.1016/0165-1781(94)90006-X",
language = "English (US)",
volume = "54",
pages = "185--198",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Selective effects of antipsychotic medications on eye-tracking performance in schizophrenia

AU - Sweeley, John A.

AU - Haas, Gretchen L.

AU - Li, Shuhua

AU - Weiden, Peter J.

PY - 1994

Y1 - 1994

N2 - The potential impact of antipsychotic medications on eye-tracking impairments in schizophrenia has received little systematic attention. To address this issue, eye-tracking performance was studied in 19 neuroliptic-naive schizophrenic patients, 22 previously medicated schizophrenic patients who had not received antipsychotic drugs for at least 28 days, and 52 nonpsychiatric control subjects. Impairments were similar but generally more severe in previously treated than in neuroleptic-naive patients. An attention-facilitation manipulation improved eye-tracking performance in all groups. Ten neuroleptic-naive and 14 previously treated cases were retested after at least 3 weeks of treatment with antipsychotic medication. Short-term treatment with neuroleptics improved certain attention-related aspects of eye tracking involving saccadic eye movements such as anticipatory saccades, but it did not alter pursuit eye movements.

AB - The potential impact of antipsychotic medications on eye-tracking impairments in schizophrenia has received little systematic attention. To address this issue, eye-tracking performance was studied in 19 neuroliptic-naive schizophrenic patients, 22 previously medicated schizophrenic patients who had not received antipsychotic drugs for at least 28 days, and 52 nonpsychiatric control subjects. Impairments were similar but generally more severe in previously treated than in neuroleptic-naive patients. An attention-facilitation manipulation improved eye-tracking performance in all groups. Ten neuroleptic-naive and 14 previously treated cases were retested after at least 3 weeks of treatment with antipsychotic medication. Short-term treatment with neuroleptics improved certain attention-related aspects of eye tracking involving saccadic eye movements such as anticipatory saccades, but it did not alter pursuit eye movements.

KW - attention

KW - eye movements

KW - Neuroleptic medication

KW - oculomotor activity

KW - saccades

UR - http://www.scopus.com/inward/record.url?scp=0028564649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028564649&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(94)90006-X

DO - 10.1016/0165-1781(94)90006-X

M3 - Article

C2 - 7761552

AN - SCOPUS:0028564649

VL - 54

SP - 185

EP - 198

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 2

ER -