Selective sensing of zinc ions with a PARACEST contrast agent

Robert Trokowski, Jimin Ren, Ferenc Krisztián Kálmán, A. Dean Sherry

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

A europium complex capable of selectively binding zinc (see picture) has been developed as a new paramagnetic chemical exchange saturation transfer (PARACEST) imaging agent for use in magnetic resonance imaging (MRI). A hydroxide group on the bound Zn ion increases the rate of water exchange on the Eu ion. (Chemical Equation Presented)

Original languageEnglish (US)
Pages (from-to)6920-6923
Number of pages4
JournalAngewandte Chemie - International Edition
Volume44
Issue number42
DOIs
StatePublished - Oct 28 2005

Fingerprint

Contrast Media
Zinc
Ions
Europium
Imaging techniques
Magnetic resonance
Ion exchange
Water
hydroxide ion

Keywords

  • Imaging agents
  • Lanthanides
  • Proton exchange
  • Saturation transfer
  • Zinc

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Selective sensing of zinc ions with a PARACEST contrast agent. / Trokowski, Robert; Ren, Jimin; Kálmán, Ferenc Krisztián; Sherry, A. Dean.

In: Angewandte Chemie - International Edition, Vol. 44, No. 42, 28.10.2005, p. 6920-6923.

Research output: Contribution to journalArticle

Trokowski, Robert ; Ren, Jimin ; Kálmán, Ferenc Krisztián ; Sherry, A. Dean. / Selective sensing of zinc ions with a PARACEST contrast agent. In: Angewandte Chemie - International Edition. 2005 ; Vol. 44, No. 42. pp. 6920-6923.
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