Selective toxin sequestrants for the treatment of bacterial infections

Levi S. Simpson, Lyle Burdine, Amal K. Dutta, Andrew P. Feranchak, Thomas Kodadek

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Bacterial toxin-mediated diarrheal disease is a major cause of morbidity and mortality worldwide. In this work we designed an on-bead library of protease-resistant, acid-stable peptoid molecules and screened for high affinity binding of cholera toxin. From 100000 compounds, we discovered a single sequence of residues that can bind and retain cholera toxin at high affinity when immobilized on a solid-phase particle. Furthermore, we demonstrate that these peptoiddisplaying particles can sequester active cholera toxin from cell culture media sufficient to protect intestinal cells. We foresee this work as contributory to a potential adjunct therapeutic strategy against cholera infections and other toxin-mediated diseases.

Original languageEnglish (US)
Pages (from-to)5760-5762
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number16
DOIs
StatePublished - Apr 29 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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