Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression

Susan G. Kornstein, A. T. Harvey, A. J. Rush, S. R. Wisniewski, M. H. Trivedi, D. S. Svikis, N. D. McKenzie, C. Bryan, R. Harley

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background. Very little research has examined the frequency with which women with major depressive disorder experience premenstrual exacerbation (PME) of depression or the characteristics of those who report such worsening. The NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provides a unique opportunity to evaluate PME in depressed women seeking treatment in primary care or psychiatric settings. Method. This report presents data from the first 1500 participants enrolled in the STAR*D study. Premenopausal women with major depressive disorder were asked if they experienced a worsening of their depressive symptoms 5-10 days prior to menses. Those reporting PME were compared with those reporting no PME with regard to sociodemographic characteristics, course of illness features, symptom presentation, general medical co-morbidity, functional impairment, and quality of life. Results. Of 433 premenopausal women not taking oral contraceptives, 64% reported a premenstrual worsening of their depression. Women who reported PME had a longer duration of their current major depressive episode [30.7 (S.D. = 73.7) months versus 13.5 (S.D. = 13.2) months; p = 0.001], as well as greater general medical co-morbidity. Women reporting PME were also more likely to endorse symptoms of leaden paralysis, somatic complaints, gastrointestinal complaints, and psychomotor slowing, and were less likely to endorse blunted mood reactivity. Conclusions. PME is endorsed by the majority of premenopausal women with major depressive disorder and appears to be associated with a longer duration of depressive episode. PME is a common and important clinical issue deserving of further attention in both research and practice.

Original languageEnglish (US)
Pages (from-to)683-692
Number of pages10
JournalPsychological Medicine
Volume35
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Depression
Major Depressive Disorder
Therapeutics
National Institute of Mental Health (U.S.)
Morbidity
Menstruation
Oral Contraceptives
Research
Paralysis
Psychiatry
Primary Health Care
Quality of Life

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression. / Kornstein, Susan G.; Harvey, A. T.; Rush, A. J.; Wisniewski, S. R.; Trivedi, M. H.; Svikis, D. S.; McKenzie, N. D.; Bryan, C.; Harley, R.

In: Psychological Medicine, Vol. 35, No. 5, 05.2005, p. 683-692.

Research output: Contribution to journalArticle

Kornstein, SG, Harvey, AT, Rush, AJ, Wisniewski, SR, Trivedi, MH, Svikis, DS, McKenzie, ND, Bryan, C & Harley, R 2005, 'Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression', Psychological Medicine, vol. 35, no. 5, pp. 683-692. https://doi.org/10.1017/S0033291704004106
Kornstein, Susan G. ; Harvey, A. T. ; Rush, A. J. ; Wisniewski, S. R. ; Trivedi, M. H. ; Svikis, D. S. ; McKenzie, N. D. ; Bryan, C. ; Harley, R. / Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression. In: Psychological Medicine. 2005 ; Vol. 35, No. 5. pp. 683-692.
@article{40a47f080f6e4c9b8af1990d21e8e8ac,
title = "Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression",
abstract = "Background. Very little research has examined the frequency with which women with major depressive disorder experience premenstrual exacerbation (PME) of depression or the characteristics of those who report such worsening. The NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provides a unique opportunity to evaluate PME in depressed women seeking treatment in primary care or psychiatric settings. Method. This report presents data from the first 1500 participants enrolled in the STAR*D study. Premenopausal women with major depressive disorder were asked if they experienced a worsening of their depressive symptoms 5-10 days prior to menses. Those reporting PME were compared with those reporting no PME with regard to sociodemographic characteristics, course of illness features, symptom presentation, general medical co-morbidity, functional impairment, and quality of life. Results. Of 433 premenopausal women not taking oral contraceptives, 64{\%} reported a premenstrual worsening of their depression. Women who reported PME had a longer duration of their current major depressive episode [30.7 (S.D. = 73.7) months versus 13.5 (S.D. = 13.2) months; p = 0.001], as well as greater general medical co-morbidity. Women reporting PME were also more likely to endorse symptoms of leaden paralysis, somatic complaints, gastrointestinal complaints, and psychomotor slowing, and were less likely to endorse blunted mood reactivity. Conclusions. PME is endorsed by the majority of premenopausal women with major depressive disorder and appears to be associated with a longer duration of depressive episode. PME is a common and important clinical issue deserving of further attention in both research and practice.",
author = "Kornstein, {Susan G.} and Harvey, {A. T.} and Rush, {A. J.} and Wisniewski, {S. R.} and Trivedi, {M. H.} and Svikis, {D. S.} and McKenzie, {N. D.} and C. Bryan and R. Harley",
year = "2005",
month = "5",
doi = "10.1017/S0033291704004106",
language = "English (US)",
volume = "35",
pages = "683--692",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "5",

}

TY - JOUR

T1 - Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression

AU - Kornstein, Susan G.

AU - Harvey, A. T.

AU - Rush, A. J.

AU - Wisniewski, S. R.

AU - Trivedi, M. H.

AU - Svikis, D. S.

AU - McKenzie, N. D.

AU - Bryan, C.

AU - Harley, R.

PY - 2005/5

Y1 - 2005/5

N2 - Background. Very little research has examined the frequency with which women with major depressive disorder experience premenstrual exacerbation (PME) of depression or the characteristics of those who report such worsening. The NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provides a unique opportunity to evaluate PME in depressed women seeking treatment in primary care or psychiatric settings. Method. This report presents data from the first 1500 participants enrolled in the STAR*D study. Premenopausal women with major depressive disorder were asked if they experienced a worsening of their depressive symptoms 5-10 days prior to menses. Those reporting PME were compared with those reporting no PME with regard to sociodemographic characteristics, course of illness features, symptom presentation, general medical co-morbidity, functional impairment, and quality of life. Results. Of 433 premenopausal women not taking oral contraceptives, 64% reported a premenstrual worsening of their depression. Women who reported PME had a longer duration of their current major depressive episode [30.7 (S.D. = 73.7) months versus 13.5 (S.D. = 13.2) months; p = 0.001], as well as greater general medical co-morbidity. Women reporting PME were also more likely to endorse symptoms of leaden paralysis, somatic complaints, gastrointestinal complaints, and psychomotor slowing, and were less likely to endorse blunted mood reactivity. Conclusions. PME is endorsed by the majority of premenopausal women with major depressive disorder and appears to be associated with a longer duration of depressive episode. PME is a common and important clinical issue deserving of further attention in both research and practice.

AB - Background. Very little research has examined the frequency with which women with major depressive disorder experience premenstrual exacerbation (PME) of depression or the characteristics of those who report such worsening. The NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provides a unique opportunity to evaluate PME in depressed women seeking treatment in primary care or psychiatric settings. Method. This report presents data from the first 1500 participants enrolled in the STAR*D study. Premenopausal women with major depressive disorder were asked if they experienced a worsening of their depressive symptoms 5-10 days prior to menses. Those reporting PME were compared with those reporting no PME with regard to sociodemographic characteristics, course of illness features, symptom presentation, general medical co-morbidity, functional impairment, and quality of life. Results. Of 433 premenopausal women not taking oral contraceptives, 64% reported a premenstrual worsening of their depression. Women who reported PME had a longer duration of their current major depressive episode [30.7 (S.D. = 73.7) months versus 13.5 (S.D. = 13.2) months; p = 0.001], as well as greater general medical co-morbidity. Women reporting PME were also more likely to endorse symptoms of leaden paralysis, somatic complaints, gastrointestinal complaints, and psychomotor slowing, and were less likely to endorse blunted mood reactivity. Conclusions. PME is endorsed by the majority of premenopausal women with major depressive disorder and appears to be associated with a longer duration of depressive episode. PME is a common and important clinical issue deserving of further attention in both research and practice.

UR - http://www.scopus.com/inward/record.url?scp=19144362575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19144362575&partnerID=8YFLogxK

U2 - 10.1017/S0033291704004106

DO - 10.1017/S0033291704004106

M3 - Article

C2 - 15918345

AN - SCOPUS:19144362575

VL - 35

SP - 683

EP - 692

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 5

ER -