SELOVS: Brain MRSI localization based on highly selective T1- and B1-insensitive outer-volume suppression at 3T

Anke Henning, Michael Schär, Rolf F. Schulte, Bertram Wilm, Klaas P. Pruessmann, Peter Boesiger

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

In vivo, high-field MR spectroscopic imaging (MRSI) profits from signal-to-noise ratio (SNR) gain and increased spectral resolution. However, bandwidth limitations of slice-selective excitation and refocusing pulses lead to strong chemical-shift displacement at high field strength when using conventional MRSI localization based on PRESS. Consequential metabolic information, particularly of border regions such as cortical brain tissue, is distorted. In addition, lipid contamination remains a major confound. To address these problems it is proposed to abandon PRESS selection and rely on a novel scheme of highly selective T1- and B1-insensitive outer-volume suppression in combination with slice-selective spin-echo acquisition for brain MRSI. Multiple cycles of overlapping suppression slabs are applied with flip angles optimized to account for tissue-dependent T 1 relaxation times and band crossings. Broadband frequency modulated saturation pulses with polynomial phase-response are utilized in order to minimize chemical-shift displacement. Efficacy of the outer-volume suppression sequence was simulated and evaluated in vitro and in vivo. Brain MRSI localization at 3T was significantly improved and reliable suppression of short-range lipid contamination enabled, leading to substantial enhancement of spectral quality, particularly in cortical tissue. Hence, the new method holds potential to expand the applicability of high-field MRSI to the entire brain.

Original languageEnglish (US)
Pages (from-to)40-51
Number of pages12
JournalMagnetic resonance in medicine
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Brain
Lipids
Signal-To-Noise Ratio
In Vitro Techniques

Keywords

  • High field
  • Localization
  • MRSI
  • Outer-volume suppression
  • Polynomial-phase response pulses
  • SELOVS
  • Slice selection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

SELOVS : Brain MRSI localization based on highly selective T1- and B1-insensitive outer-volume suppression at 3T. / Henning, Anke; Schär, Michael; Schulte, Rolf F.; Wilm, Bertram; Pruessmann, Klaas P.; Boesiger, Peter.

In: Magnetic resonance in medicine, Vol. 59, No. 1, 01.01.2008, p. 40-51.

Research output: Contribution to journalArticle

Henning, Anke ; Schär, Michael ; Schulte, Rolf F. ; Wilm, Bertram ; Pruessmann, Klaas P. ; Boesiger, Peter. / SELOVS : Brain MRSI localization based on highly selective T1- and B1-insensitive outer-volume suppression at 3T. In: Magnetic resonance in medicine. 2008 ; Vol. 59, No. 1. pp. 40-51.
@article{d009a56d2c5545799093aa79babeab99,
title = "SELOVS: Brain MRSI localization based on highly selective T1- and B1-insensitive outer-volume suppression at 3T",
abstract = "In vivo, high-field MR spectroscopic imaging (MRSI) profits from signal-to-noise ratio (SNR) gain and increased spectral resolution. However, bandwidth limitations of slice-selective excitation and refocusing pulses lead to strong chemical-shift displacement at high field strength when using conventional MRSI localization based on PRESS. Consequential metabolic information, particularly of border regions such as cortical brain tissue, is distorted. In addition, lipid contamination remains a major confound. To address these problems it is proposed to abandon PRESS selection and rely on a novel scheme of highly selective T1- and B1-insensitive outer-volume suppression in combination with slice-selective spin-echo acquisition for brain MRSI. Multiple cycles of overlapping suppression slabs are applied with flip angles optimized to account for tissue-dependent T 1 relaxation times and band crossings. Broadband frequency modulated saturation pulses with polynomial phase-response are utilized in order to minimize chemical-shift displacement. Efficacy of the outer-volume suppression sequence was simulated and evaluated in vitro and in vivo. Brain MRSI localization at 3T was significantly improved and reliable suppression of short-range lipid contamination enabled, leading to substantial enhancement of spectral quality, particularly in cortical tissue. Hence, the new method holds potential to expand the applicability of high-field MRSI to the entire brain.",
keywords = "High field, Localization, MRSI, Outer-volume suppression, Polynomial-phase response pulses, SELOVS, Slice selection",
author = "Anke Henning and Michael Sch{\"a}r and Schulte, {Rolf F.} and Bertram Wilm and Pruessmann, {Klaas P.} and Peter Boesiger",
year = "2008",
month = "1",
day = "1",
doi = "10.1002/mrm.21374",
language = "English (US)",
volume = "59",
pages = "40--51",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - SELOVS

T2 - Brain MRSI localization based on highly selective T1- and B1-insensitive outer-volume suppression at 3T

AU - Henning, Anke

AU - Schär, Michael

AU - Schulte, Rolf F.

AU - Wilm, Bertram

AU - Pruessmann, Klaas P.

AU - Boesiger, Peter

PY - 2008/1/1

Y1 - 2008/1/1

N2 - In vivo, high-field MR spectroscopic imaging (MRSI) profits from signal-to-noise ratio (SNR) gain and increased spectral resolution. However, bandwidth limitations of slice-selective excitation and refocusing pulses lead to strong chemical-shift displacement at high field strength when using conventional MRSI localization based on PRESS. Consequential metabolic information, particularly of border regions such as cortical brain tissue, is distorted. In addition, lipid contamination remains a major confound. To address these problems it is proposed to abandon PRESS selection and rely on a novel scheme of highly selective T1- and B1-insensitive outer-volume suppression in combination with slice-selective spin-echo acquisition for brain MRSI. Multiple cycles of overlapping suppression slabs are applied with flip angles optimized to account for tissue-dependent T 1 relaxation times and band crossings. Broadband frequency modulated saturation pulses with polynomial phase-response are utilized in order to minimize chemical-shift displacement. Efficacy of the outer-volume suppression sequence was simulated and evaluated in vitro and in vivo. Brain MRSI localization at 3T was significantly improved and reliable suppression of short-range lipid contamination enabled, leading to substantial enhancement of spectral quality, particularly in cortical tissue. Hence, the new method holds potential to expand the applicability of high-field MRSI to the entire brain.

AB - In vivo, high-field MR spectroscopic imaging (MRSI) profits from signal-to-noise ratio (SNR) gain and increased spectral resolution. However, bandwidth limitations of slice-selective excitation and refocusing pulses lead to strong chemical-shift displacement at high field strength when using conventional MRSI localization based on PRESS. Consequential metabolic information, particularly of border regions such as cortical brain tissue, is distorted. In addition, lipid contamination remains a major confound. To address these problems it is proposed to abandon PRESS selection and rely on a novel scheme of highly selective T1- and B1-insensitive outer-volume suppression in combination with slice-selective spin-echo acquisition for brain MRSI. Multiple cycles of overlapping suppression slabs are applied with flip angles optimized to account for tissue-dependent T 1 relaxation times and band crossings. Broadband frequency modulated saturation pulses with polynomial phase-response are utilized in order to minimize chemical-shift displacement. Efficacy of the outer-volume suppression sequence was simulated and evaluated in vitro and in vivo. Brain MRSI localization at 3T was significantly improved and reliable suppression of short-range lipid contamination enabled, leading to substantial enhancement of spectral quality, particularly in cortical tissue. Hence, the new method holds potential to expand the applicability of high-field MRSI to the entire brain.

KW - High field

KW - Localization

KW - MRSI

KW - Outer-volume suppression

KW - Polynomial-phase response pulses

KW - SELOVS

KW - Slice selection

UR - http://www.scopus.com/inward/record.url?scp=37549007917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37549007917&partnerID=8YFLogxK

U2 - 10.1002/mrm.21374

DO - 10.1002/mrm.21374

M3 - Article

C2 - 18050349

AN - SCOPUS:37549007917

VL - 59

SP - 40

EP - 51

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 1

ER -