Semilobar holoprosencephaly seen with diffusion tensor imaging and fiber tracking

Research output: Contribution to journalArticle

28 Scopus citations


A neonate with semilobar holoprosencephaly was studied with diffusion tensor imaging and fiber tracking. Fiber tracking showed that the frontooccipital fascicali were in continuity across the ventral midline, interposed between fused caudate and dysplastic fornices. Tractography of the posterior limbs of the internal capsules showed fibers arching ventrally toward the expected location of the motor cortex; some fibers also coursed dorsally, presumably to the sensory cortex. There was a posterior commissural white matter bundle representing a callosal splenium. Diffusion tensor imaging and fiber tracking revealed white matter structures not apparent on routine imaging sequences, which are in agreement with pathologic descriptions of the holoprosencephalic brain.

Original languageEnglish (US)
Pages (from-to)2148-2152
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number8
StatePublished - Dec 1 2005


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this