Semiparametric density ratio modeling of survival data from a prevalent cohort

Hong Zhu, Jing Ning, Yu Shen, Jing Qin

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In this article, we consider methods for assessing covariate effects on survival outcome in the target population when data are collected under prevalent sampling. We investigate a flexible semiparametric density ratio model without the constraints of the constant disease incidence rate and discrete covariates as required in Shen and others 2012. For inference, we introduce two likelihood approaches with distinct computational algorithms. We first develop a full likelihood approach to obtain the most efficient estimators by an iterative algorithm. Under the density ratio model, we exploit the invariance property of uncensored failure times from the prevalent cohort and also propose a computationally convenient estimation procedure that uses a conditional pairwise likelihood. The empirical performance and efficiency of the two approaches are evaluated through simulation studies. The proposed methods are applied to the Surveillance, Epidemiology, and End Results Medicare linked data for women diagnosed with stage IV breast cancer.

Original languageEnglish (US)
Pages (from-to)62-75
Number of pages14
JournalBiostatistics
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Conditional pairwise likelihood
  • Density ratio model
  • Left-truncated right-censored data
  • Prevalent sampling
  • Profile likelihood

ASJC Scopus subject areas

  • Statistics and Probability
  • Medicine(all)
  • Statistics, Probability and Uncertainty

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