Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil

J. R. Haaga, A. Exner, B. Fei, A. Seftel

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The physiologic variability of blood flow to the prostate has not been studied until this time. We report the vasoactive effects of sildenafil and phenylephrine on blood flow of the normal prostate. Sildenafil increases prostate blood flow by approximately 75% and phenylephrine reduces the flow incrementally. Administration of these drugs with dynamic contrast-enhanced magnetic resonance imaging may improve the diagnosis of cancerous tissue because according to the literature, tumor angiogenic vessels lack the vasoactive physiologic response of the normal tissue.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalInternational Journal of Impotence Research
Volume19
Issue number1
DOIs
StatePublished - 2007

Keywords

  • Angiogenesis
  • Prostate blood flow
  • Vasoactive drugs

ASJC Scopus subject areas

  • Urology

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