Sensation of the autologous reconstructed breast improves quality of life

a pilot study

Anouk J.M. Cornelissen, Jop Beugels, Sander M.J. van Kuijk, Esther M. Heuts, Shai M. Rozen, Aldona J. Spiegel, René R.W.J. van der Hulst, Stefania M.H. Tuinder

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: The number of breast cancer survivors continues to grow. Due to refinements in operating techniques, autologous breast reconstruction has become part of standard care. Impaired sensation remains a debilitating side effect with a significant impact on the quality of life. Microsurgical nerve coaptation of a sensory nerve has the potential to improve sensation of the reconstructed breast. This study investigates the effect of improved sensation of the reconstructed breast on the quality of life in breast cancer survivors. Methods: A retrospective cohort study was performed in the Maastricht University Medical Center. Patients undergoing a DIEP flap breast reconstruction between January 2015 and January 2016 were included. The primary outcome was quality of life (BREAST-Q domain ‘physical well-being of the chest’). The Semmes–Weinstein monofilaments were used for objective sensation measurement of the reconstructed breast(s). Results: Eighteen patients with and 14 patients without nerve coaptation responded. Nipple reconstruction was the only characteristic that differed statistically significant between both groups (p = 0.04). The BREAST-Q score for the domain physical well-being of the chest was 77.89 ± 18.89 on average in patients with nerve coaptation and 66.21 ± 18.26 in patients without nerve coaptation (p = 0.09). Linear regression showed a statistically significant relation between objectively measured sensation and BREAST-Q score for the domain physical well-being of the chest with a regression coefficient of − 13.17 ± 3.61 (p < 0.01). Conclusions: Improved sensation in the autologous reconstructed breast, with the addition of microsurgical nerve coaptation, has a statistical significant positive impact on the quality of life in breast cancer survivors according to the BREAST-Q.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalBreast Cancer Research and Treatment
DOIs
StateAccepted/In press - Oct 25 2017

Fingerprint

Breast
Quality of Life
Survivors
Thorax
Mammaplasty
Breast Neoplasms
Nipples
Hypesthesia
Standard of Care
Linear Models
Cohort Studies
Retrospective Studies

Keywords

  • Breast reconstruction
  • Nerve coaptation
  • Neurotisation
  • Quality of Life
  • Sensation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cornelissen, A. J. M., Beugels, J., van Kuijk, S. M. J., Heuts, E. M., Rozen, S. M., Spiegel, A. J., ... Tuinder, S. M. H. (Accepted/In press). Sensation of the autologous reconstructed breast improves quality of life: a pilot study. Breast Cancer Research and Treatment, 1-9. https://doi.org/10.1007/s10549-017-4547-3

Sensation of the autologous reconstructed breast improves quality of life : a pilot study. / Cornelissen, Anouk J.M.; Beugels, Jop; van Kuijk, Sander M.J.; Heuts, Esther M.; Rozen, Shai M.; Spiegel, Aldona J.; van der Hulst, René R.W.J.; Tuinder, Stefania M.H.

In: Breast Cancer Research and Treatment, 25.10.2017, p. 1-9.

Research output: Contribution to journalArticle

Cornelissen, AJM, Beugels, J, van Kuijk, SMJ, Heuts, EM, Rozen, SM, Spiegel, AJ, van der Hulst, RRWJ & Tuinder, SMH 2017, 'Sensation of the autologous reconstructed breast improves quality of life: a pilot study', Breast Cancer Research and Treatment, pp. 1-9. https://doi.org/10.1007/s10549-017-4547-3
Cornelissen, Anouk J.M. ; Beugels, Jop ; van Kuijk, Sander M.J. ; Heuts, Esther M. ; Rozen, Shai M. ; Spiegel, Aldona J. ; van der Hulst, René R.W.J. ; Tuinder, Stefania M.H. / Sensation of the autologous reconstructed breast improves quality of life : a pilot study. In: Breast Cancer Research and Treatment. 2017 ; pp. 1-9.
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abstract = "Purpose: The number of breast cancer survivors continues to grow. Due to refinements in operating techniques, autologous breast reconstruction has become part of standard care. Impaired sensation remains a debilitating side effect with a significant impact on the quality of life. Microsurgical nerve coaptation of a sensory nerve has the potential to improve sensation of the reconstructed breast. This study investigates the effect of improved sensation of the reconstructed breast on the quality of life in breast cancer survivors. Methods: A retrospective cohort study was performed in the Maastricht University Medical Center. Patients undergoing a DIEP flap breast reconstruction between January 2015 and January 2016 were included. The primary outcome was quality of life (BREAST-Q domain ‘physical well-being of the chest’). The Semmes–Weinstein monofilaments were used for objective sensation measurement of the reconstructed breast(s). Results: Eighteen patients with and 14 patients without nerve coaptation responded. Nipple reconstruction was the only characteristic that differed statistically significant between both groups (p = 0.04). The BREAST-Q score for the domain physical well-being of the chest was 77.89 ± 18.89 on average in patients with nerve coaptation and 66.21 ± 18.26 in patients without nerve coaptation (p = 0.09). Linear regression showed a statistically significant relation between objectively measured sensation and BREAST-Q score for the domain physical well-being of the chest with a regression coefficient of − 13.17 ± 3.61 (p < 0.01). Conclusions: Improved sensation in the autologous reconstructed breast, with the addition of microsurgical nerve coaptation, has a statistical significant positive impact on the quality of life in breast cancer survivors according to the BREAST-Q.",
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T2 - a pilot study

AU - Cornelissen, Anouk J.M.

AU - Beugels, Jop

AU - van Kuijk, Sander M.J.

AU - Heuts, Esther M.

AU - Rozen, Shai M.

AU - Spiegel, Aldona J.

AU - van der Hulst, René R.W.J.

AU - Tuinder, Stefania M.H.

PY - 2017/10/25

Y1 - 2017/10/25

N2 - Purpose: The number of breast cancer survivors continues to grow. Due to refinements in operating techniques, autologous breast reconstruction has become part of standard care. Impaired sensation remains a debilitating side effect with a significant impact on the quality of life. Microsurgical nerve coaptation of a sensory nerve has the potential to improve sensation of the reconstructed breast. This study investigates the effect of improved sensation of the reconstructed breast on the quality of life in breast cancer survivors. Methods: A retrospective cohort study was performed in the Maastricht University Medical Center. Patients undergoing a DIEP flap breast reconstruction between January 2015 and January 2016 were included. The primary outcome was quality of life (BREAST-Q domain ‘physical well-being of the chest’). The Semmes–Weinstein monofilaments were used for objective sensation measurement of the reconstructed breast(s). Results: Eighteen patients with and 14 patients without nerve coaptation responded. Nipple reconstruction was the only characteristic that differed statistically significant between both groups (p = 0.04). The BREAST-Q score for the domain physical well-being of the chest was 77.89 ± 18.89 on average in patients with nerve coaptation and 66.21 ± 18.26 in patients without nerve coaptation (p = 0.09). Linear regression showed a statistically significant relation between objectively measured sensation and BREAST-Q score for the domain physical well-being of the chest with a regression coefficient of − 13.17 ± 3.61 (p < 0.01). Conclusions: Improved sensation in the autologous reconstructed breast, with the addition of microsurgical nerve coaptation, has a statistical significant positive impact on the quality of life in breast cancer survivors according to the BREAST-Q.

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