Sensing spermidine through tongue-tied translation prevents too much of a good thing

Research output: Contribution to journalArticlepeer-review

Abstract

Vindu et al. (2021) identify the yeast high-affinity spermidine transporter, elucidate the mRNA uORF/eIF5a-based translational mechanism by which spermidine levels are sensed, and demonstrate that excess spermidine competitively inhibits eIF5a function, resulting in decreased spermidine uptake.

Original languageEnglish (US)
Pages (from-to)3882-3883
Number of pages2
JournalMolecular cell
Volume81
Issue number19
DOIs
StatePublished - Oct 7 2021

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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