Sensing spermidine through tongue-tied translation prevents too much of a good thing

Anthony J. Michael

doi:10.1016/j.molcel.2021.09.014

Sensing spermidine through tongue-tied translation prevents too much of a good thing

Research output: Contribution to journal › Article › peer-review

Abstract

Vindu et al. (2021) identify the yeast high-affinity spermidine transporter, elucidate the mRNA uORF/eIF5a-based translational mechanism by which spermidine levels are sensed, and demonstrate that excess spermidine competitively inhibits eIF5a function, resulting in decreased spermidine uptake.

Original language	English (US)
Pages (from-to)	3882-3883
Number of pages	2
Journal	Molecular cell
Volume	81
Issue number	19
DOIs	https://doi.org/10.1016/j.molcel.2021.09.014
State	Published - Oct 7 2021

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2021.09.014

Cite this

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title = "Sensing spermidine through tongue-tied translation prevents too much of a good thing",

abstract = "Vindu et al. (2021) identify the yeast high-affinity spermidine transporter, elucidate the mRNA uORF/eIF5a-based translational mechanism by which spermidine levels are sensed, and demonstrate that excess spermidine competitively inhibits eIF5a function, resulting in decreased spermidine uptake.",

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AB - Vindu et al. (2021) identify the yeast high-affinity spermidine transporter, elucidate the mRNA uORF/eIF5a-based translational mechanism by which spermidine levels are sensed, and demonstrate that excess spermidine competitively inhibits eIF5a function, resulting in decreased spermidine uptake.

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Sensing spermidine through tongue-tied translation prevents too much of a good thing

Abstract

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