Sensitivity analysis for small imaging domains using the frequency-domain transport equation

Xuejun Gu, Kui Ren, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6629
StatePublished - 2007
EventDiffuse Optical Imaging of Tissue - Munich, Germany
Duration: Jun 19 2007Jun 21 2007

Other

OtherDiffuse Optical Imaging of Tissue
CountryGermany
CityMunich
Period6/19/076/21/07

Fingerprint

Radiative transfer
Sensitivity analysis
Tissue
Imaging techniques
Light propagation
Optical tomography
Frequency modulation
Imaging systems
Optical properties
Experiments
Rodentia

Keywords

  • Equation of radiative transfer
  • Finite volume method
  • Optical tomography
  • Signal-to-noise

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Gu, X., Ren, K., & Hielscher, A. H. (2007). Sensitivity analysis for small imaging domains using the frequency-domain transport equation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6629). [66291Q]

Sensitivity analysis for small imaging domains using the frequency-domain transport equation. / Gu, Xuejun; Ren, Kui; Hielscher, Andreas H.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6629 2007. 66291Q.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gu, X, Ren, K & Hielscher, AH 2007, Sensitivity analysis for small imaging domains using the frequency-domain transport equation. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6629, 66291Q, Diffuse Optical Imaging of Tissue, Munich, Germany, 6/19/07.
Gu X, Ren K, Hielscher AH. Sensitivity analysis for small imaging domains using the frequency-domain transport equation. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6629. 2007. 66291Q
Gu, Xuejun ; Ren, Kui ; Hielscher, Andreas H. / Sensitivity analysis for small imaging domains using the frequency-domain transport equation. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6629 2007.
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