TY - GEN
T1 - Sensitivity analysis for small imaging domains using the frequency-domain transport equation
AU - Gu, Xuejun
AU - Ren, Kui
AU - Hielscher, Andreas H.
PY - 2007
Y1 - 2007
N2 - Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.
AB - Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.
KW - Equation of radiative transfer
KW - Finite volume method
KW - Optical tomography
KW - Signal-to-noise
UR - http://www.scopus.com/inward/record.url?scp=36248970667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248970667&partnerID=8YFLogxK
U2 - 10.1364/ecbo.2007.6629_62
DO - 10.1364/ecbo.2007.6629_62
M3 - Conference contribution
AN - SCOPUS:36248970667
SN - 0819467731
SN - 9780819467737
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Diffuse Optical Imaging of Tissue
PB - SPIE
T2 - Diffuse Optical Imaging of Tissue
Y2 - 19 June 2007 through 21 June 2007
ER -