Sensitivity analysis for small imaging domains using the frequency-domain transport equation

Xuejun Gu, Kui Ren, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical tomography of small tissue volumes, as they are encountered in rodent or finger imaging, holds great promise as the signal-to-noise levels are usually high and the spatial resolutions are much better than that of large imaging domains. To accurately model the light propagation in these small domains, radiative transport equations have to be solved directly. In the study at hand, we use the frequency-domain equation of radiative transfer (ERT) to perform a sensitivity study. We determine optimal source-modulation frequencies for which variations in optical properties, size, and location of a tissue inhomogeneity lead to maximal changes in the amplitude and phase of the measured signal. These results will be useful in designed experiments and optical tomographic imaging system.

Original languageEnglish (US)
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
ISBN (Print)9780819467713
Publication statusPublished - 2007
EventEuropean Conference on Biomedical Optics, ECBO 2007 - Munich, Germany
Duration: Jun 17 2007Jun 17 2007

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2007
CountryGermany
CityMunich
Period6/17/076/17/07

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Keywords

  • Equation of radiative transfer
  • Finite volume method
  • Optical tomography
  • Signal-to-noise

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Gu, X., Ren, K., & Hielscher, A. H. (2007). Sensitivity analysis for small imaging domains using the frequency-domain transport equation. In Optics InfoBase Conference Papers Optical Society of America.