Sensitivity of derived clinical biomarkers to rs-fmri preprocessing software versions

Kevin P. Nguyen, Cherise Chin Fatt, Cooper Mellema, Madhukar H. Trivedi, Albert Montillo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

When common software packages (CONN and SPM) are used to process fMRI, results such as functional connectivity measures can substantially differ depending on the versions of the packages used and the tools used to convert image formats such as DICOM to NIFTI. The significance of these differences are illustrated within the context of a realistic research application: finding moderators of antidepressant response from a large psychiatric study of 288 major depressive disorder (MDD) patients. Significant differences in functional connectivity measurements and discrepancies in derived moderators were found between nearly all software configurations. These results should encourage researchers to be vigilant of software versions during fMRI preprocessing, to maintain consistency throughout each project, and to carefully report versions to facilitate reproducibility.

Original languageEnglish (US)
Title of host publicationISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages1581-1584
Number of pages4
ISBN (Electronic)9781538636411
DOIs
StatePublished - Apr 2019
Event16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy
Duration: Apr 8 2019Apr 11 2019

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2019-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference16th IEEE International Symposium on Biomedical Imaging, ISBI 2019
CountryItaly
CityVenice
Period4/8/194/11/19

Keywords

  • Biomarkers
  • Connectivity
  • FMRI
  • Preprocessing
  • SPM

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Nguyen, K. P., Fatt, C. C., Mellema, C., Trivedi, M. H., & Montillo, A. (2019). Sensitivity of derived clinical biomarkers to rs-fmri preprocessing software versions. In ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging (pp. 1581-1584). [8759526] (Proceedings - International Symposium on Biomedical Imaging; Vol. 2019-April). IEEE Computer Society. https://doi.org/10.1109/ISBI.2019.8759526