Sensitivity of in vivo MRS of the N-δ proton in proximal histidine of deoxymyoglobin

Z. Wang, D. J. Wang, E. A. Noyszewski, A. R. Bogdan, J. C. Haselgrove, R. Reddy, R. A. Zimmerman, J. S. Leigh

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Abstract

The sensitivity of in vivo MRS of the N-δ proton of the proximal histidine of deoxymyoglobin in human skeletal muscles is discussed. Longitudinal relaxation time T1 of this deoxymyoglobin signal was measured in cuffed human forearms at 1.5 T and found to be 9.9 ms. Deoxymyoglobin spectra can be obtained from a forearm in seconds. The detection sensitivity of deoxymyoglobin in fully ischemic skeletal muscles and that of 31P MRS of PCr in normal resting muscles are compared.

Original languageEnglish (US)
Pages (from-to)362-367
Number of pages6
JournalMagnetic Resonance in Medicine
Volume27
Issue number2
DOIs
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Wang, Z., Wang, D. J., Noyszewski, E. A., Bogdan, A. R., Haselgrove, J. C., Reddy, R., ... Leigh, J. S. (1992). Sensitivity of in vivo MRS of the N-δ proton in proximal histidine of deoxymyoglobin. Magnetic Resonance in Medicine, 27(2), 362-367. https://doi.org/10.1002/mrm.1910270217