Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report

Anat R. Tambur; Patricia Campbell; Frans H. Claas; Sandy Feng; Howard M. Gebel; Annette M. Jackson; Roslyn B. Mannon; Elaine F. Reed; Kathryn Tinckam; Medhat Askar; Anil Chandraker; Patricia P. Chang; Monica Colvin; Anthony Jake Demetris; Joshua M. Diamond; Anne I. Dipchand; Robert L. Fairchild; Mandy L. Ford; John Friedewald; Ronald G. Gill; Denis Glotz; Hilary Goldberg; Ramsey Hachem; Stuart Knechtle; Jon Kobashigawa; Deborah J. Levine; Joshua Levitsky; Michael Mengel; Edgar Milford; Kenneth A. Newell; Jacqueline G. O’Leary; Scott Palmer; Parmjeet Randhawa; John Smith; Laurie Snyder; Randall C. Starling; Stuart Sweet; Timucin Taner; Craig J. Taylor; Steve Woodle; Adriana Zeevi; Peter Nickerson

doi:10.1111/ajt.14752

Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report

Anat R. Tambur, Patricia Campbell, Frans H. Claas, Sandy Feng, Howard M. Gebel, Annette M. Jackson, Roslyn B. Mannon, Elaine F. Reed, Kathryn Tinckam, Medhat Askar, Anil Chandraker, Patricia P. Chang, Monica Colvin, Anthony Jake Demetris, Joshua M. Diamond, Anne I. Dipchand, Robert L. Fairchild, Mandy L. Ford, John Friedewald, Ronald G. GillDenis Glotz, Hilary Goldberg, Ramsey Hachem, Stuart Knechtle, Jon Kobashigawa, Deborah J. Levine, Joshua Levitsky, Michael Mengel, Edgar Milford, Kenneth A. Newell, Jacqueline G. O’Leary, Scott Palmer, Parmjeet Randhawa, John Smith, Laurie Snyder, Randall C. Starling, Stuart Sweet, Timucin Taner, Craig J. Taylor, Steve Woodle, Adriana Zeevi, Peter Nickerson

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191 Scopus citations

Abstract

The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced significantly in recent years, the criteria to define presence of a DSA and assign a level of risk for a given DSA vary markedly between centers. A collaborative effort between the American Society for Histocompatibility and Immunogenetics and the American Society of Transplantation provided the logistical support for generating a dedicated multidisciplinary working group, which included experts in histocompatibility as well as kidney, liver, heart, and lung transplantation. The goals were to perform a critical review of biologically driven, state-of-the-art, clinical diagnostics literature and to provide clinical practice recommendations based on expert assessment of quality and strength of evidence. The results of the Sensitization in Transplantation: Assessment of Risk (STAR) meeting are summarized here, providing recommendations on the definition and utilization of HLA diagnostic testing, and a framework for clinical assessment of risk for a memory or a primary alloimmune response. The definitions, recommendations, risk framework, and highlighted gaps in knowledge are intended to spur research that will inform the next STAR Working Group meeting in 2019.

Original language	English (US)
Pages (from-to)	1604-1614
Number of pages	11
Journal	American Journal of Transplantation
Volume	18
Issue number	7
DOIs	https://doi.org/10.1111/ajt.14752
State	Published - Jul 2018

Keywords

alloantibody
clinical research/practice
clinical trial design
guidelines
histocompatibility
immunobiology
monitoring: immune
sensitization

ASJC Scopus subject areas

Immunology and Allergy
Transplantation
Pharmacology (medical)

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10.1111/ajt.14752

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Tambur, A. R., Campbell, P., Claas, F. H., Feng, S., Gebel, H. M., Jackson, A. M., Mannon, R. B., Reed, E. F., Tinckam, K., Askar, M., Chandraker, A., Chang, P. P., Colvin, M., Demetris, A. J., Diamond, J. M., Dipchand, A. I., Fairchild, R. L., Ford, M. L., Friedewald, J., ... Nickerson, P. (2018). Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report. American Journal of Transplantation, 18(7), 1604-1614. https://doi.org/10.1111/ajt.14752

Tambur, AR, Campbell, P, Claas, FH, Feng, S, Gebel, HM, Jackson, AM, Mannon, RB, Reed, EF, Tinckam, K, Askar, M, Chandraker, A, Chang, PP, Colvin, M, Demetris, AJ, Diamond, JM, Dipchand, AI, Fairchild, RL, Ford, ML, Friedewald, J, Gill, RG, Glotz, D, Goldberg, H, Hachem, R, Knechtle, S, Kobashigawa, J, Levine, DJ, Levitsky, J, Mengel, M, Milford, E, Newell, KA, O’Leary, JG, Palmer, S, Randhawa, P, Smith, J, Snyder, L, Starling, RC, Sweet, S, Taner, T, Taylor, CJ, Woodle, S, Zeevi, A & Nickerson, P 2018, 'Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report', American Journal of Transplantation, vol. 18, no. 7, pp. 1604-1614. https://doi.org/10.1111/ajt.14752

@article{afda3320c4d049479edfeb088a40b11b,

title = "Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report",

abstract = "The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced significantly in recent years, the criteria to define presence of a DSA and assign a level of risk for a given DSA vary markedly between centers. A collaborative effort between the American Society for Histocompatibility and Immunogenetics and the American Society of Transplantation provided the logistical support for generating a dedicated multidisciplinary working group, which included experts in histocompatibility as well as kidney, liver, heart, and lung transplantation. The goals were to perform a critical review of biologically driven, state-of-the-art, clinical diagnostics literature and to provide clinical practice recommendations based on expert assessment of quality and strength of evidence. The results of the Sensitization in Transplantation: Assessment of Risk (STAR) meeting are summarized here, providing recommendations on the definition and utilization of HLA diagnostic testing, and a framework for clinical assessment of risk for a memory or a primary alloimmune response. The definitions, recommendations, risk framework, and highlighted gaps in knowledge are intended to spur research that will inform the next STAR Working Group meeting in 2019.",

keywords = "alloantibody, clinical research/practice, clinical trial design, guidelines, histocompatibility, immunobiology, monitoring: immune, sensitization",

author = "Tambur, {Anat R.} and Patricia Campbell and Claas, {Frans H.} and Sandy Feng and Gebel, {Howard M.} and Jackson, {Annette M.} and Mannon, {Roslyn B.} and Reed, {Elaine F.} and Kathryn Tinckam and Medhat Askar and Anil Chandraker and Chang, {Patricia P.} and Monica Colvin and Demetris, {Anthony Jake} and Diamond, {Joshua M.} and Dipchand, {Anne I.} and Fairchild, {Robert L.} and Ford, {Mandy L.} and John Friedewald and Gill, {Ronald G.} and Denis Glotz and Hilary Goldberg and Ramsey Hachem and Stuart Knechtle and Jon Kobashigawa and Levine, {Deborah J.} and Joshua Levitsky and Michael Mengel and Edgar Milford and Newell, {Kenneth A.} and O{\textquoteright}Leary, {Jacqueline G.} and Scott Palmer and Parmjeet Randhawa and John Smith and Laurie Snyder and Starling, {Randall C.} and Stuart Sweet and Timucin Taner and Taylor, {Craig J.} and Steve Woodle and Adriana Zeevi and Peter Nickerson",

note = "Publisher Copyright: {\textcopyright} 2018 The American Society of Transplantation and the American Society of Transplant Surgeons",

year = "2018",

month = jul,

doi = "10.1111/ajt.14752",

language = "English (US)",

volume = "18",

pages = "1604--1614",

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T2 - Assessment of Risk (STAR) 2017 Working Group Meeting Report

AU - Tambur, Anat R.

AU - Campbell, Patricia

AU - Claas, Frans H.

AU - Feng, Sandy

AU - Gebel, Howard M.

AU - Jackson, Annette M.

AU - Mannon, Roslyn B.

AU - Reed, Elaine F.

AU - Tinckam, Kathryn

AU - Askar, Medhat

AU - Chandraker, Anil

AU - Chang, Patricia P.

AU - Colvin, Monica

AU - Demetris, Anthony Jake

AU - Diamond, Joshua M.

AU - Dipchand, Anne I.

AU - Fairchild, Robert L.

AU - Ford, Mandy L.

AU - Friedewald, John

AU - Gill, Ronald G.

AU - Glotz, Denis

AU - Goldberg, Hilary

AU - Hachem, Ramsey

AU - Knechtle, Stuart

AU - Kobashigawa, Jon

AU - Levine, Deborah J.

AU - Levitsky, Joshua

AU - Mengel, Michael

AU - Milford, Edgar

AU - Newell, Kenneth A.

AU - O’Leary, Jacqueline G.

AU - Palmer, Scott

AU - Randhawa, Parmjeet

AU - Smith, John

AU - Snyder, Laurie

AU - Starling, Randall C.

AU - Sweet, Stuart

AU - Taner, Timucin

AU - Taylor, Craig J.

AU - Woodle, Steve

AU - Zeevi, Adriana

AU - Nickerson, Peter

PY - 2018/7

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AB - The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced significantly in recent years, the criteria to define presence of a DSA and assign a level of risk for a given DSA vary markedly between centers. A collaborative effort between the American Society for Histocompatibility and Immunogenetics and the American Society of Transplantation provided the logistical support for generating a dedicated multidisciplinary working group, which included experts in histocompatibility as well as kidney, liver, heart, and lung transplantation. The goals were to perform a critical review of biologically driven, state-of-the-art, clinical diagnostics literature and to provide clinical practice recommendations based on expert assessment of quality and strength of evidence. The results of the Sensitization in Transplantation: Assessment of Risk (STAR) meeting are summarized here, providing recommendations on the definition and utilization of HLA diagnostic testing, and a framework for clinical assessment of risk for a memory or a primary alloimmune response. The definitions, recommendations, risk framework, and highlighted gaps in knowledge are intended to spur research that will inform the next STAR Working Group meeting in 2019.

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KW - guidelines

KW - histocompatibility

KW - immunobiology

KW - monitoring: immune

KW - sensitization

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Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report

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Keywords

ASJC Scopus subject areas

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