TY - JOUR
T1 - Sensors of the innate immune system
T2 - Their mode of action
AU - Baccala, Roberto
AU - Gonzalez-Quintial, Rosana
AU - Lawson, Brian R.
AU - Stern, Michael E.
AU - Kono, Dwight H.
AU - Beutler, Bruce
AU - Theofilopoulos, Argyrios N.
PY - 2009/8
Y1 - 2009/8
N2 - The discovery of molecular sensors that enable eukaryotes to recognize microbial pathogens and their products has been a key advance in our understanding of innate immunity. A tripartite sensing apparatus has developed to detect danger signals from infectious agents and damaged tissues, resulting in an immediate but short-lived defense response. This apparatus includes Toll-like receptors, retinoid acid-inducible gene-I-like receptors and other cytosolic nucleic acid sensors, and nucleotide-binding and oligomerization domain-like receptors; adaptors, kinases and other signaling molecules are required to elicit effective responses. Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders.
AB - The discovery of molecular sensors that enable eukaryotes to recognize microbial pathogens and their products has been a key advance in our understanding of innate immunity. A tripartite sensing apparatus has developed to detect danger signals from infectious agents and damaged tissues, resulting in an immediate but short-lived defense response. This apparatus includes Toll-like receptors, retinoid acid-inducible gene-I-like receptors and other cytosolic nucleic acid sensors, and nucleotide-binding and oligomerization domain-like receptors; adaptors, kinases and other signaling molecules are required to elicit effective responses. Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders.
UR - http://www.scopus.com/inward/record.url?scp=71249128612&partnerID=8YFLogxK
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U2 - 10.1038/nrrheum.2009.136
DO - 10.1038/nrrheum.2009.136
M3 - Review article
C2 - 19597511
AN - SCOPUS:71249128612
SN - 1759-4790
VL - 5
SP - 448
EP - 456
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
IS - 8
ER -