Sensors of the innate immune system: Their mode of action

Roberto Baccala, Rosana Gonzalez-Quintial, Brian R. Lawson, Michael E. Stern, Dwight H. Kono, Bruce Beutler, Argyrios N. Theofilopoulos

Research output: Contribution to journalReview article

77 Scopus citations

Abstract

The discovery of molecular sensors that enable eukaryotes to recognize microbial pathogens and their products has been a key advance in our understanding of innate immunity. A tripartite sensing apparatus has developed to detect danger signals from infectious agents and damaged tissues, resulting in an immediate but short-lived defense response. This apparatus includes Toll-like receptors, retinoid acid-inducible gene-I-like receptors and other cytosolic nucleic acid sensors, and nucleotide-binding and oligomerization domain-like receptors; adaptors, kinases and other signaling molecules are required to elicit effective responses. Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders.

Original languageEnglish (US)
Pages (from-to)448-456
Number of pages9
JournalNature Reviews Rheumatology
Volume5
Issue number8
DOIs
StatePublished - Aug 2009

ASJC Scopus subject areas

  • Rheumatology

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    Baccala, R., Gonzalez-Quintial, R., Lawson, B. R., Stern, M. E., Kono, D. H., Beutler, B., & Theofilopoulos, A. N. (2009). Sensors of the innate immune system: Their mode of action. Nature Reviews Rheumatology, 5(8), 448-456. https://doi.org/10.1038/nrrheum.2009.136