Sensors of the innate immune system

their mode of action.

Roberto Baccala, Rosana Gonzalez-Quintial, Brian R. Lawson, Michael E. Stern, Dwight H. Kono, Bruce Beutler, Argyrios N. Theofilopoulos

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The discovery of molecular sensors that enable eukaryotes to recognize microbial pathogens and their products has been a key advance in our understanding of innate immunity. A tripartite sensing apparatus has developed to detect danger signals from infectious agents and damaged tissues, resulting in an immediate but short-lived defense response. This apparatus includes Toll-like receptors, retinoid acid-inducible gene-I-like receptors and other cytosolic nucleic acid sensors, and nucleotide-binding and oligomerization domain-like receptors; adaptors, kinases and other signaling molecules are required to elicit effective responses. Although this sensing is beneficial to the host, excessive activation and/or engagement by self molecules might induce autoimmune and other inflammatory disorders.

Original languageEnglish (US)
Pages (from-to)448-456
Number of pages9
JournalNature reviews. Rheumatology
Volume5
Issue number8
StatePublished - Aug 2009

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Toll-Like Receptors
Retinoids
Eukaryota
Innate Immunity
Nucleic Acids
Immune System
Phosphotransferases
Nucleotides
Acids
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Baccala, R., Gonzalez-Quintial, R., Lawson, B. R., Stern, M. E., Kono, D. H., Beutler, B., & Theofilopoulos, A. N. (2009). Sensors of the innate immune system: their mode of action. Nature reviews. Rheumatology, 5(8), 448-456.

Sensors of the innate immune system : their mode of action. / Baccala, Roberto; Gonzalez-Quintial, Rosana; Lawson, Brian R.; Stern, Michael E.; Kono, Dwight H.; Beutler, Bruce; Theofilopoulos, Argyrios N.

In: Nature reviews. Rheumatology, Vol. 5, No. 8, 08.2009, p. 448-456.

Research output: Contribution to journalArticle

Baccala, R, Gonzalez-Quintial, R, Lawson, BR, Stern, ME, Kono, DH, Beutler, B & Theofilopoulos, AN 2009, 'Sensors of the innate immune system: their mode of action.', Nature reviews. Rheumatology, vol. 5, no. 8, pp. 448-456.
Baccala R, Gonzalez-Quintial R, Lawson BR, Stern ME, Kono DH, Beutler B et al. Sensors of the innate immune system: their mode of action. Nature reviews. Rheumatology. 2009 Aug;5(8):448-456.
Baccala, Roberto ; Gonzalez-Quintial, Rosana ; Lawson, Brian R. ; Stern, Michael E. ; Kono, Dwight H. ; Beutler, Bruce ; Theofilopoulos, Argyrios N. / Sensors of the innate immune system : their mode of action. In: Nature reviews. Rheumatology. 2009 ; Vol. 5, No. 8. pp. 448-456.
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