Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release

Seungwon Choi, Kelsey P. Taylor, Marios Chatzigeorgiou, Zhitao Hu, William R. Schafer, Joshua M. Kaplan

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

C. elegans undergoes periods of behavioral quiescence during larval molts (termed lethargus) and as adults. Little is known about the circuit mechanisms that establish these quiescent states. Lethargus and adult locomotion quiescence is dramatically reduced in mutants lacking the neuropeptide receptor NPR-1. Here, we show that the aroused locomotion of npr-1 mutants results from the exaggerated activity in multiple classes of sensory neurons, including nociceptive (ASH), touch sensitive (ALM and PLM), and stretch sensing (DVA) neurons. These sensory neurons accelerate locomotion via both neuropeptide and glutamate release. The relative contribution of these sensory neurons to arousal differs between larval molts and adults. Our results suggest that a broad network of sensory neurons dictates transitions between aroused and quiescent behavioral states.

Original languageEnglish (US)
Article numbere1005359
JournalPLoS genetics
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

Fingerprint

Dive into the research topics of 'Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release'. Together they form a unique fingerprint.

Cite this