Sentinel lymph node biopsy, an alternative to elective axillary dissection for breast cancer

Fiemu E. Nwariaku, David M. Euhus, Peter D. Beitsch, Edward Clifford, William Erdman, Dana Mathews, Jorge Albores-Saavedra, Marilyn A. Leitch, George N. Peters

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

BACKGROUND: Axillary metastases remain an important prognostic indicator in breast cancer. Axillary lymphadenectomy (ALND) carries significant morbidity and is unnecessary in most patients with early breast cancer; thus, sentinel lymph node (SLN) biopsy has been advocated for axillary staging. We studied the SLN identification rate and its accuracy in predicting axillary metastases. METHODS: One hundred nineteen women with breast carcinoma underwent SLN and ALND. Lymphoscintigraphy was performed using Technetium99 sulfur colloid supplemented by Isosulfan blue dye. Hematoxylin/eosin-stained lymph node sections were examined by light microscopy. RESULTS: The SLN identification rate was 81%. One SLN was negative (1%) in a patient with axillary disease. SLN histology correctly predicted the absence of axillary disease in 98.6%. Sensitivity, specificity, and positive and negative predictive values were 96%, 100%, 100%, and 99%, respectively. CONCLUSIONS: Sentinel lymph node biopsy accurately predicts total axillary status and is valuable in the surgical staging of breast cancer.

Original languageEnglish (US)
Pages (from-to)529-531
Number of pages3
JournalAmerican journal of surgery
Volume176
Issue number6
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Surgery

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