Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography

Chulhong Kim, Kwang Hyun Song, Lihong V. Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We apply ultrasound-modulated optical tomography (UOT) to image ex-vivo methylene-blue-dyed sentinel lymph nodes embedded in 3.2-cm-thick chicken breast tissues. The UOT system is implemented for the first time using ring-shaped light illumination, intense acoustic bursts, and charge-coupled device (CCD) camera-based speckle contrast detection. Since the system is noninvasive, nonionizing, portable, relatively cost effective, and easy to combine with photoacoustic imaging and single element ultrasonic pulse-echo imaging, UOT can potentially be a good imaging modality for the detection of sentinel lymph nodes in breast cancer staging in vivo.

Original languageEnglish (US)
Article number020507
JournalJournal of Biomedical Optics
Volume13
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

lymphatic system
Optical tomography
tomography
Ultrasonics
breast
Imaging techniques
chickens
methylene blue
Photoacoustic effect
Methylene Blue
charge coupled devices
bursts
echoes
CCD cameras
Speckle
ultrasonics
cancer
illumination
cameras
costs

Keywords

  • Acoustic bursts
  • Axillary lymph node dissection
  • Breast cancer
  • Sentinel lymph node biopsy
  • Speckle contrast
  • Ultrasound-modulated optical tomography

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography. / Kim, Chulhong; Song, Kwang Hyun; Wang, Lihong V.

In: Journal of Biomedical Optics, Vol. 13, No. 2, 020507, 03.2008.

Research output: Contribution to journalArticle

Kim, Chulhong ; Song, Kwang Hyun ; Wang, Lihong V. / Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography. In: Journal of Biomedical Optics. 2008 ; Vol. 13, No. 2.
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