Abstract
We apply ultrasound-modulated optical tomography (UOT) to image ex-vivo methylene-blue-dyed sentinel lymph nodes embedded in 3.2-cm-thick chicken breast tissues. The UOT system is implemented for the first time using ring-shaped light illumination, intense acoustic bursts, and charge-coupled device (CCD) camera-based speckle contrast detection. Since the system is noninvasive, nonionizing, portable, relatively cost effective, and easy to combine with photoacoustic imaging and single element ultrasonic pulse-echo imaging, UOT can potentially be a good imaging modality for the detection of sentinel lymph nodes in breast cancer staging in vivo.
Original language | English (US) |
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Article number | 020507 |
Journal | Journal of biomedical optics |
Volume | 13 |
Issue number | 2 |
DOIs | |
State | Published - 2008 |
Keywords
- acoustic bursts
- axillary lymph node dissection
- breast cancer
- sentinel lymph node biopsy
- speckle contrast
- ultrasound-modulated optical tomography
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomedical Engineering
- Biomaterials