Separable regulatory elements governing myogenin transcription in mouse embryogenesis

Tse Chang Cheng, Mia C. Wallace, John P. Merlie, Eric N. Olson

Research output: Contribution to journalArticle

219 Scopus citations

Abstract

Expression of the myogenic helix-loop-helix (HLH) protein myogenin in muscle cell precursors within somites and limb buds is among the earliest events associated with myogenic lineage determination in vertebrates. Mutations in the myogenin promoter that abolish binding sites for myogenic HLH proteins or myocyte enhancer factor-2 (MEF-2) suppressed transcription of a linked lacZ transgene in subsets of myogenic precursors in mouse embryos. These results suggest that myogenic HLH proteins and MEF-2 participate in separable regulatory circuits leading to myogenin transcription and provide evidence for positional regulation of myogenic regulators in the embryo.

Original languageEnglish (US)
Pages (from-to)215-218
Number of pages4
JournalScience
Volume261
Issue number5118
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • General

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