Separating the good and evil of cardiac growth by CIB1 and calcineurin

Robert J A Frost, Eric N. Olson

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

Ca 2+ -calcineurin-NFAT signaling plays a major role in promoting pathological cardiac hypertrophy. Heineke et al. (2010) show that CIB1 strongly enhances calcineurin activation and cardiac hypertrophy upon pathological stress, likely by functioning as a scaffold protein that exposes calcineurin to the L-Type Ca 2+ channel and the sarcolemma.

Original languageEnglish (US)
Pages (from-to)205-206
Number of pages2
JournalCell Metabolism
Volume12
Issue number3
DOIs
StatePublished - Sep 8 2010

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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