Abstract
Ca 2+ -calcineurin-NFAT signaling plays a major role in promoting pathological cardiac hypertrophy. Heineke et al. (2010) show that CIB1 strongly enhances calcineurin activation and cardiac hypertrophy upon pathological stress, likely by functioning as a scaffold protein that exposes calcineurin to the L-Type Ca 2+ channel and the sarcolemma.
Original language | English (US) |
---|---|
Pages (from-to) | 205-206 |
Number of pages | 2 |
Journal | Cell Metabolism |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Sep 8 2010 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology