Sequence analysis of enzymes with asparaginase activity

Dominika Borek, Mariusz Jaskólski

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Asparaginases catalyze the hydrolysis of asparagine to aspartic acid and ammonia. Enzymes with asparaginase activity play an important role both in the metabolism of all living organisms as well as in pharmacology. The main goal of this paper is to attempt a classification of all known enzymes with asparaginase activity, based on their amino acid sequences. Some possible phylogenetic consequences are also discussed using dendrograms and structural information derived from crystallographic studies.

Original languageEnglish (US)
Pages (from-to)893-902
Number of pages10
JournalActa Biochimica Polonica
Volume48
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Asparaginase
  • Aspartylglucosaminidase
  • L-asparagine
  • Lysophospholipase
  • N-terminal nucleophile hydrolase
  • tRNA amidotransferase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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