TY - JOUR
T1 - Sequence-dependent conformational variations in the b-dna double-helix of poly d(Aatt) poly d(aatt)
AU - Chandrasekaran, R.
AU - Radha, A.
AU - Ratliff, R. L.
N1 - Funding Information:
We thank the National Institutes of Health for financial support, and Professor Strother Arnott for helpful discussions.
PY - 1994/2
Y1 - 1994/2
N2 - X-ray diffraction data from well oriented and polycrystalline fibers of the lithium salt of poly d(AATT) poly d(AATT) are isomorphous with those from B-DNA The double-helix consists of conformationally identical antiparallel strands and the molecular symmetry is 2 52; the asymmetric unit is a tetranucleotide, AATT, and 5 tetranucleotides span two turns per strand. Two double helices pass through a monoclinic unit cell of dimensions a = 31.05, b = 22.62, c = 33.85 Å (fiber axis) and γ = 90°. In each repeating motif, the four nucleotides have distinct conformations, TpA displays an axial P-O bond and there is shortening of minor groove in the central region.
AB - X-ray diffraction data from well oriented and polycrystalline fibers of the lithium salt of poly d(AATT) poly d(AATT) are isomorphous with those from B-DNA The double-helix consists of conformationally identical antiparallel strands and the molecular symmetry is 2 52; the asymmetric unit is a tetranucleotide, AATT, and 5 tetranucleotides span two turns per strand. Two double helices pass through a monoclinic unit cell of dimensions a = 31.05, b = 22.62, c = 33.85 Å (fiber axis) and γ = 90°. In each repeating motif, the four nucleotides have distinct conformations, TpA displays an axial P-O bond and there is shortening of minor groove in the central region.
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U2 - 10.1080/07391102.1994.10508030
DO - 10.1080/07391102.1994.10508030
M3 - Article
C2 - 8204212
AN - SCOPUS:0028348630
SN - 0739-1102
VL - 11
SP - 741
EP - 766
JO - Journal of Biomolecular Structure and Dynamics
JF - Journal of Biomolecular Structure and Dynamics
IS - 4
ER -