TY - JOUR
T1 - Sequence of immunoglobulin changes resulting from an attack of infectious mononucleosis
AU - Allansmith, Mathea
AU - Bergstresser, Paul
N1 - Funding Information:
This twenty-three year old man felt well when the initial blood sample was obtained. Several days later he began to feel ill, with general malaise and feelings of an impending “cold.” The second blood sample was obtained one week after the first, and at this time the * Performed by Dr. J. S. Remington, Palo .\lto Research Foundation, Palo Alto, California. t Performed by Dr. Kenneth Vosti, Department of Medicine, Stanford University School of Medicine. Palo .41to, California. (See [5] .) * From the Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California. This investigation was supported by Research Grant E320 from the American Cancer Society and by Public Health Service Training Grant 5 Tl 82 from the National Institute of Allergy and Infections Disease. Manuscript received January 19, 1967.
PY - 1968/1
Y1 - 1968/1
N2 - Infectious mononucleosis developed in a young man whose IgG, IgA and IgM levels were being studied once a week. The levels of all three globulins increased significantly. The greatest increase (425 per cent) was in IgM, followed by IgA (104 per cent) and IgG (44 per cent). The induction times for all appeared to be the same. IgM and IgA each required about one week to reach peak values, whereas IgG required several weeks. Although the titer of the heterophil antibody was high, the immunoglobulin levels did not decrease after its removal.
AB - Infectious mononucleosis developed in a young man whose IgG, IgA and IgM levels were being studied once a week. The levels of all three globulins increased significantly. The greatest increase (425 per cent) was in IgM, followed by IgA (104 per cent) and IgG (44 per cent). The induction times for all appeared to be the same. IgM and IgA each required about one week to reach peak values, whereas IgG required several weeks. Although the titer of the heterophil antibody was high, the immunoglobulin levels did not decrease after its removal.
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U2 - 10.1016/0002-9343(68)90243-X
DO - 10.1016/0002-9343(68)90243-X
M3 - Article
C2 - 4169574
AN - SCOPUS:0014243836
SN - 0002-9343
VL - 44
SP - 124
EP - 127
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 1
ER -