Infectious mononucleosis developed in a young man whose IgG, IgA and IgM levels were being studied once a week. The levels of all three globulins increased significantly. The greatest increase (425 per cent) was in IgM, followed by IgA (104 per cent) and IgG (44 per cent). The induction times for all appeared to be the same. IgM and IgA each required about one week to reach peak values, whereas IgG required several weeks. Although the titer of the heterophil antibody was high, the immunoglobulin levels did not decrease after its removal.
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