Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase

Lindsey L. Morris, Isamu Z. Hartman, Dong Jae Jun, Joachim Seemann, Russell A. DeBose-Boyd

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Mechanisms for sterol- and geranylgeraniol-induced dislocation of reductase from ER membranes into cytosol for degradation are unclear. Results: VCP/p97 mediates extraction of reductase across ER membranes, whereas the proteasome 19 S regulatory particle (RP) dislodges extracted reductase into cytosol. Conclusion: VCP/p97 and proteasome 19 S RP mediate sequential steps in reductase degradation. Significance: These results define a new step in the reductase degradative pathway.

Original languageEnglish (US)
Pages (from-to)19053-19066
Number of pages14
JournalJournal of Biological Chemistry
Volume289
Issue number27
DOIs
StatePublished - Jul 4 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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