Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase

Lindsey L. Morris; Isamu Z. Hartman; Dong Jae Jun; Joachim Seemann; Russell A. DeBose-Boyd

doi:10.1074/jbc.M114.576652

Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase

Lindsey L. Morris, Isamu Z. Hartman, Dong Jae Jun, Joachim Seemann, Russell A. DeBose-Boyd

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Mechanisms for sterol- and geranylgeraniol-induced dislocation of reductase from ER membranes into cytosol for degradation are unclear. Results: VCP/p97 mediates extraction of reductase across ER membranes, whereas the proteasome 19 S regulatory particle (RP) dislodges extracted reductase into cytosol. Conclusion: VCP/p97 and proteasome 19 S RP mediate sequential steps in reductase degradation. Significance: These results define a new step in the reductase degradative pathway.

Original language	English (US)
Pages (from-to)	19053-19066
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M114.576652
State	Published - Jul 4 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Morris, L. L., Hartman, I. Z., Jun, D. J., Seemann, J., & A. DeBose-Boyd, R. (2014). Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase. Journal of Biological Chemistry, 289(27), 19053-19066. https://doi.org/10.1074/jbc.M114.576652

Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase. / Morris, Lindsey L.; Hartman, Isamu Z.; Jun, Dong Jae et al.
In: Journal of Biological Chemistry, Vol. 289, No. 27, 04.07.2014, p. 19053-19066.

Research output: Contribution to journal › Article › peer-review

Morris, LL, Hartman, IZ, Jun, DJ, Seemann, J & A. DeBose-Boyd, R 2014, 'Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase', Journal of Biological Chemistry, vol. 289, no. 27, pp. 19053-19066. https://doi.org/10.1074/jbc.M114.576652

Morris LL, Hartman IZ, Jun DJ, Seemann J, A. DeBose-Boyd R. Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase. Journal of Biological Chemistry. 2014 Jul 4;289(27):19053-19066. doi: 10.1074/jbc.M114.576652

Morris, Lindsey L. ; Hartman, Isamu Z. ; Jun, Dong Jae et al. / Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 27. pp. 19053-19066.

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abstract = "Background: Mechanisms for sterol- and geranylgeraniol-induced dislocation of reductase from ER membranes into cytosol for degradation are unclear. Results: VCP/p97 mediates extraction of reductase across ER membranes, whereas the proteasome 19 S regulatory particle (RP) dislodges extracted reductase into cytosol. Conclusion: VCP/p97 and proteasome 19 S RP mediate sequential steps in reductase degradation. Significance: These results define a new step in the reductase degradative pathway.",

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Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, Endoplasmic reticulum (ER)- associated degradation of 3-Hydroxy-3-methylglutarylcoenzyme a reductase

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