TY - JOUR
T1 - Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
AU - Iwashima, Makio
AU - Irving, Bryan A.
AU - Van Oers, Nicolai S C
AU - Chan, Andrew C.
AU - Weiss, Arthur
PY - 2014/11/1
Y1 - 2014/11/1
N2 - The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCRζ and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation of two conserved tyrosine residues in an ARAM. This phosphorylation leads to the recruitment of a second cytoplasmic PTK, ZAP-70, through both of the ZAP-70 Src homology 2 domains and its phosphorylation. Thus, TCR signal transduction is initiated by the sequential interaction of two PTKs with TCR ARAMs.
AB - The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCRζ and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation of two conserved tyrosine residues in an ARAM. This phosphorylation leads to the recruitment of a second cytoplasmic PTK, ZAP-70, through both of the ZAP-70 Src homology 2 domains and its phosphorylation. Thus, TCR signal transduction is initiated by the sequential interaction of two PTKs with TCR ARAMs.
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U2 - 10.1126/science.7509083
DO - 10.1126/science.7509083
M3 - Article
C2 - 25326545
AN - SCOPUS:84908136170
SN - 0022-1767
VL - 193
SP - 4279
EP - 4282
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -