Abstract
Background: Lecithin cholesterol acyl transferase (LCAT) deficiency is a rare autosomal recessive disorder of lipoprotein metabolism that results in end-stage renal disease (ESRD) necessitating transplantation. As LCAT is produced in the liver, combined kidney and liver transplantation was proposed to cure the clinical syndrome of LCAT deficiency. Methods: A 29-year-old male with ESRD secondary to LCAT deficiency underwent a sequential kidney–liver transplantation from the same living donor (LD). One year following the kidney transplant, auxiliary partial orthotopic liver transplant (APOLT) of a left lateral segment from the same donor was performed. Results: At 5 years follow-up, there have been no major complications, readmissions, or rejection episodes. Serum lipid abnormalities recurred within the first year, but liver and kidney allograft function remains intact. Conclusion: Few cases of sequential transplantation from the same LD have been performed in adults. This is the first APOLT and multi-organ transplant performed for LCAT deficiency. Sequential organ transplant from the same LD for ESRD secondary to a metabolic disorder of the liver is feasible in adults and should be further investigated.
Original language | English (US) |
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Pages (from-to) | 1370-1374 |
Number of pages | 5 |
Journal | Clinical Transplantation |
Volume | 30 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2016 |
Externally published | Yes |
Keywords
- auxiliary liver transplantation
- kidney transplantation
- liver transplantation
- living donor transplantation
- sequential organ transplant
ASJC Scopus subject areas
- Transplantation