Sequential Parenteral to Oral Clindamycin Dosing in Pediatric Musculoskeletal Infection: A Retrospective Review of 30mg/kg/day vs 40mg/kg/day

Cole M. Erickson, Paul K. Sue, Kyana Stewart, Michelle I. Thomas, Eduardo A. Lindsay, Chan Hee Jo, Lawson A B Copley

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

BACKGROUND:: Children with musculoskeletal infection in MRSA prevalent communities are often treated with oral clindamycin. Current guidelines recommend approximately 40 mg/kg/day for MRSA infections. This study investigates the clinical practice of using 30 mg/kg/day of clindamycin as an alternative for outpatient dosing. METHODS:: Children with musculoskeletal infection treated with outpatient clindamycin from 2009 to 2014 were studied by retrospective review. The amount of clindamycin administered was determined from dose, interval, and duration of outpatient treatment. Hospital readmission, surgeries, and sequelae were assessed. Severity of illness was determined for children with osteomyelitis. The readmission rate of 25 children treated with 40 mg/kg/day was compared with that of 190 children treated with 30 mg/kg/day. The reason for readmission was evaluated to consider if antibiotic dosing strategy was a potential factor. RESULTS:: Among 215 children studied, the average outpatient duration of treatment was 32.8 days. There was no significant difference in the rate of readmission between dosing cohorts. Severity of illness scores (0 to 10 scale) were significantly higher among readmitted children with osteomyelitis (mean 9.8 + 0.4) than among those with osteomyelitis who were not readmitted (mean 2.9 + 3.2), p=0.001. Sequelae were more common in the high-dose group and were noted in three children (12.0%) in that cohort compared to six children (3.2%) in the low-dose cohort (P>0.05). CONCLUSION:: Oral dosing of 30 mg/kg/day was effective for musculoskeletal infection in children in an MRSA prevalent community. Illness severity appeared to have greater impact on readmission and sequelae than did antibiotic dosing.

Original languageEnglish (US)
JournalPediatric Infectious Disease Journal
DOIs
StateAccepted/In press - Jun 10 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

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