Serial fiberoptic bronchoscopy during chemotherapy for small cell carcinoma of the lung. Early detection of patients at high risk of relapse

D. C. Ihde, M. H. Cohen, A. M. Bernath, M. J. Matthews, P. A. Bunn, J. D. Minna

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Serial fiberoptic bronchoscopic examinations were performed during intensive chemotherapy with a combination of drugs in 77 previously untreated patients with small cell carcinoma of the lung. Before treatment, bronchoscopic examination revealed evidence of cancer in 93% (70) of the 75 patients studied at that time, including 8% (six) in whom the tumor was not evaluable on the chest x-ray film. After therapy was initiated, 36% (29) of the 81 procedures performed in patients with a complete response radiographically and 62% (33) of the 53 bronchoscopic procedures in those with a partial response or no response showed evidence of tumor. In both of these groups, patients with abnormal findings on endoscopic examination had a much higher rate of relapsing tumor of the chest within a 12-week period. Progression of intrathoracic tumor was first detected solely by bronchoscopic examination in 22% (seven) of the 32 episodes of progression. In our hands, repeated fiberoptic bronchoscopic procedures during chemotherapy for small cell carcinoma have yielded information not apparent from the chest x-ray film in a significant number of patients.

Original languageEnglish (US)
Pages (from-to)531-536
Number of pages6
JournalUnknown Journal
Volume74
Issue number5
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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