Serial measurements of GRF in infants using the continuous iothalamate infusion technique

Malcolm Holliday; Jon Block; Martin Glasser; Jane Turner; Suzanne Young; Julie DuBois; Jon Hidayat; Jean Harrah; Phillip L. Berry; Andrea Forbes; Ronald J. Hogg; Tracy Shuck; Kaye Green; Frank Boineau; Karen Welling; Watson C. Arnold; Donna Floyd-Gimon; Gary M. Lum; Jeff Paulsen; Gail D'Amico; F. Bruder Stapleton; Patti Lawson; Judy Vinson; Ben H. Brouhard; Lisa Hollander; Susan Gemma; Susan B. Conley; Ann Ince; Ricardo Uauy; Joan Reisch; Steven Alexander; Nancy Simonds; Cynthia Cunningham; Eileen Brewer; Miriam Turner; Jean Tealey; Greg Done; Patricia Reading; Cynthia Terrill

doi:10.1038/ki.1993.125

Serial measurements of GRF in infants using the continuous iothalamate infusion technique

Malcolm Holliday, Jon Block, Martin Glasser, Jane Turner, Suzanne Young, Julie DuBois, Jon Hidayat, Jean Harrah, Phillip L. Berry, Andrea Forbes, Ronald J. Hogg, Tracy Shuck, Kaye Green, Frank Boineau, Karen Welling, Watson C. Arnold, Donna Floyd-Gimon, Gary M. Lum, Jeff Paulsen, Gail D'AmicoF. Bruder Stapleton, Patti Lawson, Judy Vinson, Ben H. Brouhard, Lisa Hollander, Susan Gemma, Susan B. Conley, Ann Ince, Ricardo Uauy, Joan Reisch, Steven Alexander, Nancy Simonds, Cynthia Cunningham, Eileen Brewer, Miriam Turner, Jean Tealey, Greg Done, Patricia Reading, Cynthia Terrill

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Abstract

We undertook a preliminary study to determine if a clinical trial was feasible that would compare the effect of a low protein vs a control formula on GFR and growth in infants with congenital renal insufficiency (C(Io) < 55 ml/min/1.73 m²). In this report from the Infant Diet Protein Study, we describe validation of a method using the plasma clearance of iothalamate (C(Io)) as an estimate of glomerular filtration rate (GFR) and results of the preliminary study relating to renal function. The plasma C(Io) method was validated as an accurate estimate of GFR by showing it to be the same as the plasma clearance of inulin (C(In)). In the preliminary study infants who qualified for the study were randomly assigned to a low protein or control formula and were followed from 8 to 18 months of age. C(Io) was measured at 8, 14 and 18 months of age in 21 of the infants and at 8 and 18 months of age in all twenty four infants that entered the study. Average absolute GFR in the 24 infants increased in the 10 month period from 5.3 ± 2.7 to 7.6 ± 4.5 ml/min. The percent increase in GFR was no different in infants ose GFR at 8 months of age was severely reduced from those whose GFR was only moderately reduced. When adjusted for age and body size, GFR did not change. Change in mean C(Io) or serum creatinine (S(Cr)) from 8 to 18 months of age between the infants in each diet groups was not different. We conclude that a clinical trial enrolling more infants and extending the study period is necessary to evaluate dietary protein effect.

Original language	English (US)
Pages (from-to)	893-898
Number of pages	6
Journal	Kidney international
Volume	43
Issue number	4
DOIs	https://doi.org/10.1038/ki.1993.125
State	Published - 1993

ASJC Scopus subject areas

Nephrology

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10.1038/ki.1993.125

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Holliday, M., Block, J., Glasser, M., Turner, J., Young, S., DuBois, J., Hidayat, J., Harrah, J., Berry, P. L., Forbes, A., Hogg, R. J., Shuck, T., Green, K., Boineau, F., Welling, K., Arnold, W. C., Floyd-Gimon, D., Lum, G. M., Paulsen, J., ... Terrill, C. (1993). Serial measurements of GRF in infants using the continuous iothalamate infusion technique. Kidney international, 43(4), 893-898. https://doi.org/10.1038/ki.1993.125

Holliday, M, Block, J, Glasser, M, Turner, J, Young, S, DuBois, J, Hidayat, J, Harrah, J, Berry, PL, Forbes, A, Hogg, RJ, Shuck, T, Green, K, Boineau, F, Welling, K, Arnold, WC, Floyd-Gimon, D, Lum, GM, Paulsen, J, D'Amico, G, Stapleton, FB, Lawson, P, Vinson, J, Brouhard, BH, Hollander, L, Gemma, S, Conley, SB, Ince, A, Uauy, R, Reisch, J, Alexander, S, Simonds, N, Cunningham, C, Brewer, E, Turner, M, Tealey, J, Done, G, Reading, P & Terrill, C 1993, 'Serial measurements of GRF in infants using the continuous iothalamate infusion technique', Kidney international, vol. 43, no. 4, pp. 893-898. https://doi.org/10.1038/ki.1993.125

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title = "Serial measurements of GRF in infants using the continuous iothalamate infusion technique",

abstract = "We undertook a preliminary study to determine if a clinical trial was feasible that would compare the effect of a low protein vs a control formula on GFR and growth in infants with congenital renal insufficiency (C(Io) < 55 ml/min/1.73 m2). In this report from the Infant Diet Protein Study, we describe validation of a method using the plasma clearance of iothalamate (C(Io)) as an estimate of glomerular filtration rate (GFR) and results of the preliminary study relating to renal function. The plasma C(Io) method was validated as an accurate estimate of GFR by showing it to be the same as the plasma clearance of inulin (C(In)). In the preliminary study infants who qualified for the study were randomly assigned to a low protein or control formula and were followed from 8 to 18 months of age. C(Io) was measured at 8, 14 and 18 months of age in 21 of the infants and at 8 and 18 months of age in all twenty four infants that entered the study. Average absolute GFR in the 24 infants increased in the 10 month period from 5.3 ± 2.7 to 7.6 ± 4.5 ml/min. The percent increase in GFR was no different in infants ose GFR at 8 months of age was severely reduced from those whose GFR was only moderately reduced. When adjusted for age and body size, GFR did not change. Change in mean C(Io) or serum creatinine (S(Cr)) from 8 to 18 months of age between the infants in each diet groups was not different. We conclude that a clinical trial enrolling more infants and extending the study period is necessary to evaluate dietary protein effect.",

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AU - Young, Suzanne

AU - DuBois, Julie

AU - Hidayat, Jon

AU - Harrah, Jean

AU - Berry, Phillip L.

AU - Forbes, Andrea

AU - Hogg, Ronald J.

AU - Shuck, Tracy

AU - Green, Kaye

AU - Boineau, Frank

AU - Welling, Karen

AU - Arnold, Watson C.

AU - Floyd-Gimon, Donna

AU - Lum, Gary M.

AU - Paulsen, Jeff

AU - D'Amico, Gail

AU - Stapleton, F. Bruder

AU - Lawson, Patti

AU - Vinson, Judy

AU - Brouhard, Ben H.

AU - Hollander, Lisa

AU - Gemma, Susan

AU - Conley, Susan B.

AU - Ince, Ann

AU - Uauy, Ricardo

AU - Reisch, Joan

AU - Alexander, Steven

AU - Simonds, Nancy

AU - Cunningham, Cynthia

AU - Brewer, Eileen

AU - Turner, Miriam

AU - Tealey, Jean

AU - Done, Greg

AU - Reading, Patricia

AU - Terrill, Cynthia

PY - 1993

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Serial measurements of GRF in infants using the continuous iothalamate infusion technique

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