Serial plasma fibrinogen changes accompanying sickle cell pain crisis

A. A. Famodu, M. O. Adedeji, H. L. Reid

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Serial measurements of plasma fibrinogen concentrations have been made in nine homozygous sickle cell disease (SCD) patients during vaso-occlusive crisis. Fibrinogen was measured by the clot-weight technique. Changes in fibrinogen concentration showed a typical pattern, rising sharply and significantly to a maximum on approximately the second day of the onset of pain crisis and after treatment was instituted. Because of the well-defined and consistent response of this acute-phase reactant protein, this study suggests that serial measurements of fibrinogen could be used as a sensitive parameter to monitor the progression of sickle cell pain crisis.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalClinical and Laboratory Haematology
Volume12
Issue number1
StatePublished - 1990

Fingerprint

Fibrinogen
Plasmas
Pain
Acute-Phase Proteins
Sickle Cell Anemia
Weights and Measures
Proteins
Therapeutics

Keywords

  • Plasma fibrinogen
  • sickle cell anaemia
  • vaso-occlusive crisis

ASJC Scopus subject areas

  • Hematology

Cite this

Serial plasma fibrinogen changes accompanying sickle cell pain crisis. / Famodu, A. A.; Adedeji, M. O.; Reid, H. L.

In: Clinical and Laboratory Haematology, Vol. 12, No. 1, 1990, p. 43-47.

Research output: Contribution to journalArticle

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