Abstract
Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.
Original language | English (US) |
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Pages (from-to) | 285-286 |
Number of pages | 2 |
Journal | Cell Metabolism |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - Sep 7 2011 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology