Serine metabolism

Some tumors take the road less traveled

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.

Original languageEnglish (US)
Pages (from-to)285-286
Number of pages2
JournalCell Metabolism
Volume14
Issue number3
DOIs
StatePublished - Sep 7 2011

Fingerprint

Serine
Phosphoglycerate Dehydrogenase
Neoplasms
Enzymes
Growth
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Serine metabolism : Some tumors take the road less traveled. / Deberardinis, Ralph J.

In: Cell Metabolism, Vol. 14, No. 3, 07.09.2011, p. 285-286.

Research output: Contribution to journalArticle

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