Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk

S. S. Lo, A. Sahgal, E. L. Chang, N. A. Mayr, B. S. Teh, Z. Huang, T. E. Schefter, M. Yao, M. Machtay, B. J. Slotman, R. D. Timmerman

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Abstract

The clinical applications of stereotactic body radiotherapy or stereotactic ablative radiotherapy (SABR) for the treatment of primary and metastatic tumours of different organ sites have been expanding rapidly in the recent decade. SABR requires advanced technology in radiotherapy planning and image guidance to deliver a highly conformal ablative dose precisely to targets (or tumours) in the body. Although this treatment modality has shown promising results with regard to tumour control, some serious complications have been observed and reported. In order to achieve a favourable therapeutic ratio, strategies to mitigate the risk of complications must be in place. This overview will summarise the reported serious complications caused by SABR and strategies to mitigate the risk will be discussed.

Original languageEnglish (US)
Pages (from-to)378-387
Number of pages10
JournalClinical Oncology
Volume25
Issue number6
DOIs
StatePublished - Jun 1 2013

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Keywords

  • Risk
  • Serious complications
  • Stereotactic ablative radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Lo, S. S., Sahgal, A., Chang, E. L., Mayr, N. A., Teh, B. S., Huang, Z., Schefter, T. E., Yao, M., Machtay, M., Slotman, B. J., & Timmerman, R. D. (2013). Serious Complications Associated with Stereotactic Ablative Radiotherapy and Strategies to Mitigate the Risk. Clinical Oncology, 25(6), 378-387. https://doi.org/10.1016/j.clon.2013.01.003