Seroepidemiology of group I human coronaviruses in children

Xiuping Shao, Xiaojie Guo, Frank Esper, Carla Weibel, Jeffrey Kahn

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: Recently, several new human coronaviruses have been identified. Objectives: To define the seroepidemiology of group I human coronaviruses. Study design: A recombinant protein enzyme linked immunosorbent assay (ELISA) based on portions of the nucleocapsid protein of group I human coronaviruses was developed and was used to screen serum from 243 children and young adults. Results: For HCoV-229E, the percentages of seropositive individuals were 57.1% for infants <2 months old; 38.9% for infants 2-3 months old; 4.7% for infants 4-5 months old; 42.9-50.0% for infants 6-12 months old; 34.8-62.5% for individuals 1-20 years old. For HCoV-NL63, the percentages of seropositive individuals were 45.2% for infants <2 months old; 11.1% for infants 2-3 months old; 4.7% for infants 4-5 months old; 28.6-40.0% for infants 6-12 months old; 25.0-70.3% for individuals 1-20 years old. Conclusions: Infection with these viruses is common in childhood though the prevalence of these viruses may vary from year to year.

Original languageEnglish (US)
Pages (from-to)207-213
Number of pages7
JournalJournal of Clinical Virology
Volume40
Issue number3
DOIs
StatePublished - Nov 1 2007

Keywords

  • Human coronavirus
  • Nucleocapsid
  • Seroepidemiology

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Seroepidemiology of group I human coronaviruses in children'. Together they form a unique fingerprint.

  • Cite this