Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt; Yuwei Zhu; Carlos G. Grijalva; Richard G. Wunderink; D. Mark Courtney; Grant Waterer; Min Z. Levine; Stacie Jefferson; Wesley H. Self; Derek J. Williams; Lynn Finelli; Anna M. Bramley; Kathryn M. Edwards; Seema Jain; Evan J. Anderson

doi:10.1111/irv.12622

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt, Yuwei Zhu, Carlos G. Grijalva, Richard G. Wunderink, D. Mark Courtney, Grant Waterer, Min Z. Levine, Stacie Jefferson, Wesley H. Self, Derek J. Williams, Lynn Finelli, Anna M. Bramley, Kathryn M. Edwards, Seema Jain, Evan J. Anderson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

Original language	English (US)
Pages (from-to)	208-212
Number of pages	5
Journal	Influenza and other respiratory viruses
Volume	13
Issue number	2
DOIs	https://doi.org/10.1111/irv.12622
State	Published - Mar 1 2019
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1111/irv.12622

Cite this

Pratt, C. Q., Zhu, Y., Grijalva, C. G., Wunderink, R. G., Mark Courtney, D., Waterer, G., Levine, M. Z., Jefferson, S., Self, W. H., Williams, D. J., Finelli, L., Bramley, A. M., Edwards, K. M., Jain, S., & Anderson, E. J. (2019). Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia. Influenza and other respiratory viruses, 13(2), 208-212. https://doi.org/10.1111/irv.12622

Pratt, CQ, Zhu, Y, Grijalva, CG, Wunderink, RG, Mark Courtney, D, Waterer, G, Levine, MZ, Jefferson, S, Self, WH, Williams, DJ, Finelli, L, Bramley, AM, Edwards, KM, Jain, S & Anderson, EJ 2019, 'Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia', Influenza and other respiratory viruses, vol. 13, no. 2, pp. 208-212. https://doi.org/10.1111/irv.12622

@article{1a0c896b250d4dbb8c8688817b2e16b6,

title = "Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia",

abstract = "Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.",

author = "Pratt, {Caroline Quinn} and Yuwei Zhu and Grijalva, {Carlos G.} and Wunderink, {Richard G.} and {Mark Courtney}, D. and Grant Waterer and Levine, {Min Z.} and Stacie Jefferson and Self, {Wesley H.} and Williams, {Derek J.} and Lynn Finelli and Bramley, {Anna M.} and Edwards, {Kathryn M.} and Seema Jain and Anderson, {Evan J.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.",

year = "2019",

month = mar,

day = "1",

doi = "10.1111/irv.12622",

language = "English (US)",

volume = "13",

pages = "208--212",

journal = "Influenza and other respiratory viruses",

issn = "1750-2640",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

AU - Pratt, Caroline Quinn

AU - Zhu, Yuwei

AU - Grijalva, Carlos G.

AU - Wunderink, Richard G.

AU - Mark Courtney, D.

AU - Waterer, Grant

AU - Levine, Min Z.

AU - Jefferson, Stacie

AU - Self, Wesley H.

AU - Williams, Derek J.

AU - Finelli, Lynn

AU - Bramley, Anna M.

AU - Edwards, Kathryn M.

AU - Jain, Seema

AU - Anderson, Evan J.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

AB - Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

UR - http://www.scopus.com/inward/record.url?scp=85061858738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061858738&partnerID=8YFLogxK

U2 - 10.1111/irv.12622

DO - 10.1111/irv.12622

M3 - Article

C2 - 30485702

AN - SCOPUS:85061858738

SN - 1750-2640

VL - 13

SP - 208

EP - 212

JO - Influenza and other respiratory viruses

JF - Influenza and other respiratory viruses

IS - 2

ER -

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this