Seroprevalence to Bartonella quintana among patients at a community clinic in downtown Seattle

Lisa A. Jackson, David H. Spach, Deborah A. Kippen, Nancy K. Sugg, Russell L. Regnery, Merlyn H. Sayers, Walter E. Stamm

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79 Scopus citations

Abstract

In 1993, an outbreak of 10 cases of Bartonella quintana bacteremia occurred among homeless, alcoholic, human immunodeficiency virus (HIV)- negative persons in Seattle. To estimate the prevalence of past exposure B. quintana among this population, a serosurvey was conducted in 1994 among patients at a downtown Seattle clinic. Microimmunofluorescent titers to B. quintana in 192 clinic patients were compared with titers in 199 age- and sex-matched Seattle volunteer blood donors. Titers ≥64 were detected in 20% (39/192) of clinic patients compared with 2% (4/199) of blood donors (P < .001). Among clinic patients, alcohol abuse was independently associated in multivariate analysis with titers ≥64 (odds ratio, 3.3; 95% confidence interval, 1.6-6.9). Of the 39 patients with B. quintana titers ≥64, 24 (62%) also had titers ≥64 to Bartonella henselae, indicating serologic cross- reactivity between Bartonella species. These results suggest that a substantial proportion of this indigent, inner-city Seattle population was infected with B. quintana.

Original languageEnglish (US)
Pages (from-to)1023-1026
Number of pages4
JournalJournal of Infectious Diseases
Volume173
Issue number4
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Jackson, L. A., Spach, D. H., Kippen, D. A., Sugg, N. K., Regnery, R. L., Sayers, M. H., & Stamm, W. E. (1996). Seroprevalence to Bartonella quintana among patients at a community clinic in downtown Seattle. Journal of Infectious Diseases, 173(4), 1023-1026. https://doi.org/10.1093/infdis/173.4.1023