Serotonergic control of metabolic homeostasis

Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu

Research output: Contribution to journalShort surveypeer-review

48 Scopus citations


New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

Original languageEnglish (US)
Article number277
JournalFrontiers in Cellular Neuroscience
StatePublished - Sep 20 2017


  • Adipose tissue
  • Diabetes
  • Feeding
  • Gluconeogenesis
  • Obesity
  • Pancreas
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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