Serotonergic control of metabolic homeostasis

Steven C. Wyler; Caleb C. Lord; Syann Lee; Joel K. Elmquist; Chen Liu

doi:10.3389/fncel.2017.00277

Serotonergic control of metabolic homeostasis

Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu

Research output: Contribution to journal › Short survey › peer-review

53 Scopus citations

Abstract

New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

Original language	English (US)
Article number	277
Journal	Frontiers in Cellular Neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fncel.2017.00277
State	Published - Sep 20 2017

Keywords

Adipose tissue
Diabetes
Feeding
Gluconeogenesis
Obesity
Pancreas
Serotonin

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

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10.3389/fncel.2017.00277

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title = "Serotonergic control of metabolic homeostasis",

abstract = "New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.",

keywords = "Adipose tissue, Diabetes, Feeding, Gluconeogenesis, Obesity, Pancreas, Serotonin",

author = "Wyler, {Steven C.} and Lord, {Caleb C.} and Syann Lee and Elmquist, {Joel K.} and Chen Liu",

note = "Publisher Copyright: {\textcopyright} 2017 Wyler, Lord, Lee, Elmquist and Liu.",

year = "2017",

month = sep,

day = "20",

doi = "10.3389/fncel.2017.00277",

language = "English (US)",

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T1 - Serotonergic control of metabolic homeostasis

AU - Wyler, Steven C.

AU - Lord, Caleb C.

AU - Lee, Syann

AU - Elmquist, Joel K.

AU - Liu, Chen

PY - 2017/9/20

Y1 - 2017/9/20

N2 - New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

AB - New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

KW - Adipose tissue

KW - Diabetes

KW - Feeding

KW - Gluconeogenesis

KW - Obesity

KW - Pancreas

KW - Serotonin

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DO - 10.3389/fncel.2017.00277

M3 - Short survey

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AN - SCOPUS:85031996524

SN - 1662-5102

VL - 11

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

M1 - 277

ER -

Serotonergic control of metabolic homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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