Serotonergic control of metabolic homeostasis

Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu

Research output: Contribution to journalShort survey

15 Scopus citations

Abstract

New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

Original languageEnglish (US)
Article number277
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
StatePublished - Sep 20 2017

Keywords

  • Adipose tissue
  • Diabetes
  • Feeding
  • Gluconeogenesis
  • Obesity
  • Pancreas
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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