Serotonergic control of metabolic homeostasis

Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu

Research output: Contribution to journalShort survey

8 Citations (Scopus)

Abstract

New treatments are urgently needed to address the current epidemic of obesity and diabetes. Recent studies have highlighted multiple pathways whereby serotonin (5-HT) modulates energy homeostasis, leading to a renewed interest in the identification of 5-HT-based therapies for metabolic disease. This review aims to synthesize pharmacological and genetic studies that have found diverse functions of both central and peripheral 5-HT in the control of food intake, thermogenesis, and glucose and lipid metabolism. We also discuss the potential benefits of targeting the 5-HT system to combat metabolic disease.

Original languageEnglish (US)
Article number277
JournalFrontiers in Cellular Neuroscience
Volume11
DOIs
StatePublished - Sep 20 2017

Fingerprint

Serotonin
Homeostasis
Metabolic Diseases
Thermogenesis
Lipid Metabolism
Obesity
Eating
Pharmacology
Glucose
Therapeutics

Keywords

  • Adipose tissue
  • Diabetes
  • Feeding
  • Gluconeogenesis
  • Obesity
  • Pancreas
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Serotonergic control of metabolic homeostasis. / Wyler, Steven C.; Lord, Caleb C.; Lee, Syann; Elmquist, Joel K.; Liu, Chen.

In: Frontiers in Cellular Neuroscience, Vol. 11, 277, 20.09.2017.

Research output: Contribution to journalShort survey

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