TY - JOUR
T1 - Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits
AU - Cavaccini, Anna
AU - Gritti, Marta
AU - Giorgi, Andrea
AU - Locarno, Andrea
AU - Heck, Nicolas
AU - Migliarini, Sara
AU - Bertero, Alice
AU - Mereu, Maddalena
AU - Margiani, Giulia
AU - Trusel, Massimo
AU - Catelani, Tiziano
AU - Marotta, Roberto
AU - De Luca, Maria Antonietta
AU - Caboche, Jocelyne
AU - Gozzi, Alessandro
AU - Pasqualetti, Massimo
AU - Tonini, Raffaella
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/5/16
Y1 - 2018/5/16
N2 - Monoaminergic modulation of cortical and thalamic inputs to the dorsal striatum (DS) is crucial for reward-based learning and action control. While dopamine has been extensively investigated in this context, the synaptic effects of serotonin (5-HT) have been largely unexplored. Here, we investigated how serotonergic signaling affects associative plasticity at glutamatergic synapses on the striatal projection neurons of the direct pathway (dSPNs). Combining chemogenetic and optogenetic approaches reveals that impeding serotonergic signaling preferentially gates spike-timing-dependent long-term depression (t-LTD) at thalamostriatal synapses. This t-LTD requires dampened activity of the 5-HT4 receptor subtype, which we demonstrate controls dendritic Ca2+ signals by regulating BK channel activity, and which preferentially localizes at the dendritic shaft. The synaptic effects of 5-HT signaling at thalamostriatal inputs provide insights into how changes in serotonergic levels associated with behavioral states or pathology affect striatal-dependent processes. Cavaccini and Gritti et al. combine chemogenetic and optogenetic approaches to show that serotonergic signaling provides a control mechanism of synaptic plasticity at thalamic inputs to the striatum.
AB - Monoaminergic modulation of cortical and thalamic inputs to the dorsal striatum (DS) is crucial for reward-based learning and action control. While dopamine has been extensively investigated in this context, the synaptic effects of serotonin (5-HT) have been largely unexplored. Here, we investigated how serotonergic signaling affects associative plasticity at glutamatergic synapses on the striatal projection neurons of the direct pathway (dSPNs). Combining chemogenetic and optogenetic approaches reveals that impeding serotonergic signaling preferentially gates spike-timing-dependent long-term depression (t-LTD) at thalamostriatal synapses. This t-LTD requires dampened activity of the 5-HT4 receptor subtype, which we demonstrate controls dendritic Ca2+ signals by regulating BK channel activity, and which preferentially localizes at the dendritic shaft. The synaptic effects of 5-HT signaling at thalamostriatal inputs provide insights into how changes in serotonergic levels associated with behavioral states or pathology affect striatal-dependent processes. Cavaccini and Gritti et al. combine chemogenetic and optogenetic approaches to show that serotonergic signaling provides a control mechanism of synaptic plasticity at thalamic inputs to the striatum.
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UR - http://www.scopus.com/inward/citedby.url?scp=85046115464&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2018.04.008
DO - 10.1016/j.neuron.2018.04.008
M3 - Article
C2 - 29706583
AN - SCOPUS:85046115464
SN - 0896-6273
VL - 98
SP - 801-816.e7
JO - Neuron
JF - Neuron
IS - 4
ER -