Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels

Jong Woo Sohn, Yong Xu, Juli E. Jones, Kevin Wickman, Kevin W. Williams, Joel K. Elmquist

Research output: Contribution to journalArticle

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Abstract

Serotonin 2C receptors (5-HT2CRs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT2CRs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT2CR agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT2CR and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.

Original languageEnglish (US)
Pages (from-to)488-497
Number of pages10
JournalNeuron
Volume71
Issue number3
DOIs
StatePublished - Aug 11 2011

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ASJC Scopus subject areas

  • Neuroscience(all)

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