Serotonin in the raphe nuclei

Regulation by light and an endogenous pacemaker

F. R A Cagampang, S. Yamazaki, Y. Otori, S. T. Inouye

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark phase. In constant dark (DD) condition, a single peak was observed and was out of phase to the 5-HT peak found under LD condition. Animals exposed to constant light (LL) after 2 days in DD showed marked increase in 5-HT after lights on. These results suggest that changes in 5-HT in the MRN and DRN are regulated by an endogenous pacemaker and by light.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalNeuroReport
Volume5
Issue number1
StatePublished - 1993

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Raphe Nuclei
Serotonin
Light
Periodicity
Lighting

Keywords

  • circadian rhythm
  • HPLC
  • raphe nuclei
  • rat
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cagampang, F. R. A., Yamazaki, S., Otori, Y., & Inouye, S. T. (1993). Serotonin in the raphe nuclei: Regulation by light and an endogenous pacemaker. NeuroReport, 5(1), 49-52.

Serotonin in the raphe nuclei : Regulation by light and an endogenous pacemaker. / Cagampang, F. R A; Yamazaki, S.; Otori, Y.; Inouye, S. T.

In: NeuroReport, Vol. 5, No. 1, 1993, p. 49-52.

Research output: Contribution to journalArticle

Cagampang, FRA, Yamazaki, S, Otori, Y & Inouye, ST 1993, 'Serotonin in the raphe nuclei: Regulation by light and an endogenous pacemaker', NeuroReport, vol. 5, no. 1, pp. 49-52.
Cagampang, F. R A ; Yamazaki, S. ; Otori, Y. ; Inouye, S. T. / Serotonin in the raphe nuclei : Regulation by light and an endogenous pacemaker. In: NeuroReport. 1993 ; Vol. 5, No. 1. pp. 49-52.
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