Serotonin-induced disruption of implantation in the rat

II. Suppression of decidualization.

J. A. Mitchell, Robert E Hammer, H. Goldman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Subcutaneous injection of serotonin (20 mg/kg) on Day 5 of pregnancy disrupts implantation in the rat as indicated by the reduction in number of live fetuses/cornu present on Day 19 (0.9 vs. 6.1, treated vs. control). Such disruption of implantation possibly results from impaired decidualization. To test for suppression of decidualization, serotonin was administered to pseudopregnant rats on the day before, on (Day 4) or after artificial induction of the decidual cell reaction. Relative to saline-treated controls (C), serotonin (S) reduced decidualization when injected either before [C: 1987 +/- 130 vs. S: 1085 +/- 155 mg (Day 3); P less than 0.005] or after [C: 1987 +/- 130 vs. S: 173 +/- 8 mg (Day 5); P less than 0.001] administration of the deciduogenic stimulus. In addition, serotonin markedly decreased uterine blood flow (C: 0.47 +/- 0.05 vs. S: 0.25 +/- 0.06 ml/min per g; P less than 0.01) during pseudopregnancy. However, serotonin altered neither the duration of luteal function in pseudopregnant rats (C: 15.3 vs. S: 14.3 days) nor serum progesterone levels (C: 74-91 vs. S: 53-82 ng/ml) in pregnant animals. It is concluded that serotonin may disrupt implantation, in part, by suppression of decidualization. The loss of endometrial competence to undergo decidualization appears to be a consequence of serotonin-induced uterine ischemia rather than impaired corpus luteum activity.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalBiology of Reproduction
Volume29
Issue number1
StatePublished - Aug 1983

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Serotonin
Corpus Luteum
Pseudopregnancy
Subcutaneous Injections
Mental Competency
Progesterone
Fetus
Ischemia
Pregnancy
Serum

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Embryology

Cite this

Serotonin-induced disruption of implantation in the rat : II. Suppression of decidualization. / Mitchell, J. A.; Hammer, Robert E; Goldman, H.

In: Biology of Reproduction, Vol. 29, No. 1, 08.1983, p. 151-156.

Research output: Contribution to journalArticle

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