Sertindole, a new antipsychotic drug

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Abstract

The new generation of antipsychotic drugs is all the more wellcome following the extended drug development void between 1978 and 1990. Sertindole, the newest compound to be introduced, was prospectively designed based on the depolarization block model to be a potent antipsychotic with minimal or no motor side effects. Indeed, clinical studies show that sertindole has a potent therapeutic effect on positive and negative symptoms of psychosis, while producing placebo-level motor side effects including parkinsonism and akathisia. The other reported side effect, QT interval prolongation, has not been associated with any adverse cardiac event(s). In summary, sertindole has a potent antipsychotic action with an advantageous motor side-effect profile, and is thus an important new addition to the neuroleptic armamentarium.

Original languageEnglish (US)
Pages (from-to)267-281
Number of pages15
JournalToday's Therapeutic Trends
Volume14
Issue number4
StatePublished - 1997

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Antipsychotic Agents
Psychomotor Agitation
Parkinsonian Disorders
Therapeutic Uses
Psychotic Disorders
Placebos
sertindole
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sertindole, a new antipsychotic drug. / Tamminga, C. A.

In: Today's Therapeutic Trends, Vol. 14, No. 4, 1997, p. 267-281.

Research output: Contribution to journalArticle

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