Serum antibodies to cytomegalovirus in myasthenia gravis: Effects of thymectomy and steroids

R. S A Tindall, R. Cloud, J. Luby, R. N. Rosenberg

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The etiology of the immunologic abnormalities in Myasthenia gravis (MG) remains unknown. Evidence for persistent viral infection was sought by determining serum antibody titers to several enveloped RNA and DNA viruses. Compared to healthy controls matched for age, sex, geography and socioeconomic status, patients with MG were more likely to have elevated titers of complement fixing antibody to cytomegalovirus (CMV). Patients with MG not treated with thymectomy or steroids had elevated CMV titers, whereas thymectomized or steroid-treated patients did not; the differences were statistically significant (p<0.01). These results are consistent with the hypothesis that there is persistent viral antigenic stimulation in the myasthenic thymus, arising from viral protein incorporation into epithelioid-myloid cell surface membranes and subsequent induction of an antibody to these acetylcholine receptor (AChR)-bearing thymic cells. This antibody then cross-reacts with AChR at the neuromuscular junction.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalNeurology
Volume28
Issue number3
StatePublished - 1978

Fingerprint

Thymectomy
Myasthenia Gravis
Cytomegalovirus
Steroids
Antibodies
Cholinergic Receptors
Serum
Epithelioid Cells
Geography
DNA Viruses
Neuromuscular Junction
RNA Viruses
Muscle Weakness
Viral Proteins
Virus Diseases
Social Class
Thymus Gland
Cell Membrane

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Serum antibodies to cytomegalovirus in myasthenia gravis : Effects of thymectomy and steroids. / Tindall, R. S A; Cloud, R.; Luby, J.; Rosenberg, R. N.

In: Neurology, Vol. 28, No. 3, 1978, p. 273-277.

Research output: Contribution to journalArticle

@article{b10d75c391284003965e232d93c997e7,
title = "Serum antibodies to cytomegalovirus in myasthenia gravis: Effects of thymectomy and steroids",
abstract = "The etiology of the immunologic abnormalities in Myasthenia gravis (MG) remains unknown. Evidence for persistent viral infection was sought by determining serum antibody titers to several enveloped RNA and DNA viruses. Compared to healthy controls matched for age, sex, geography and socioeconomic status, patients with MG were more likely to have elevated titers of complement fixing antibody to cytomegalovirus (CMV). Patients with MG not treated with thymectomy or steroids had elevated CMV titers, whereas thymectomized or steroid-treated patients did not; the differences were statistically significant (p<0.01). These results are consistent with the hypothesis that there is persistent viral antigenic stimulation in the myasthenic thymus, arising from viral protein incorporation into epithelioid-myloid cell surface membranes and subsequent induction of an antibody to these acetylcholine receptor (AChR)-bearing thymic cells. This antibody then cross-reacts with AChR at the neuromuscular junction.",
author = "Tindall, {R. S A} and R. Cloud and J. Luby and Rosenberg, {R. N.}",
year = "1978",
language = "English (US)",
volume = "28",
pages = "273--277",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Serum antibodies to cytomegalovirus in myasthenia gravis

T2 - Effects of thymectomy and steroids

AU - Tindall, R. S A

AU - Cloud, R.

AU - Luby, J.

AU - Rosenberg, R. N.

PY - 1978

Y1 - 1978

N2 - The etiology of the immunologic abnormalities in Myasthenia gravis (MG) remains unknown. Evidence for persistent viral infection was sought by determining serum antibody titers to several enveloped RNA and DNA viruses. Compared to healthy controls matched for age, sex, geography and socioeconomic status, patients with MG were more likely to have elevated titers of complement fixing antibody to cytomegalovirus (CMV). Patients with MG not treated with thymectomy or steroids had elevated CMV titers, whereas thymectomized or steroid-treated patients did not; the differences were statistically significant (p<0.01). These results are consistent with the hypothesis that there is persistent viral antigenic stimulation in the myasthenic thymus, arising from viral protein incorporation into epithelioid-myloid cell surface membranes and subsequent induction of an antibody to these acetylcholine receptor (AChR)-bearing thymic cells. This antibody then cross-reacts with AChR at the neuromuscular junction.

AB - The etiology of the immunologic abnormalities in Myasthenia gravis (MG) remains unknown. Evidence for persistent viral infection was sought by determining serum antibody titers to several enveloped RNA and DNA viruses. Compared to healthy controls matched for age, sex, geography and socioeconomic status, patients with MG were more likely to have elevated titers of complement fixing antibody to cytomegalovirus (CMV). Patients with MG not treated with thymectomy or steroids had elevated CMV titers, whereas thymectomized or steroid-treated patients did not; the differences were statistically significant (p<0.01). These results are consistent with the hypothesis that there is persistent viral antigenic stimulation in the myasthenic thymus, arising from viral protein incorporation into epithelioid-myloid cell surface membranes and subsequent induction of an antibody to these acetylcholine receptor (AChR)-bearing thymic cells. This antibody then cross-reacts with AChR at the neuromuscular junction.

UR - http://www.scopus.com/inward/record.url?scp=0017807097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017807097&partnerID=8YFLogxK

M3 - Article

C2 - 203876

AN - SCOPUS:0017807097

VL - 28

SP - 273

EP - 277

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -