Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia

Philip Barter, Y. Ruth McPherson, Kijoung Song, Y. Antero Kesäniemi, Robert Mahley, Gérard Waeber, Thomas Bersot, Vincent Mooser, Dawn Waterworth, Scott M Grundy

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Context: The worldwide epidemic of overweight and obesity is setting the scene for a new wave of premature cardiovascular disease. Objective: The objective of this study was to define relationships between dyslipidemia and other metabolic abnormalities in overweight subjects. Design: This study included comparison of overweight subjects with and without dyslipidemia. Setting: The setting was an institutional practice. Patients: Dyslipidemic subjects (n = 715) had plasma triglyceride greater than or equal to the 75th percentile in combination with high-density lipoprotein cholesterol (HDL-C) less than or equal to the 25th percentile. Unrelated, normolipidemic controls (n = 1073) had HDL-C higher than the median and triglyceride lower than the median. It was a requirement for the control subjects to have a body mass index (BMI) greater than 25 kg/m2. Main Outcome Measures: The main outcome measures included BMI, inflammatory markers, adipokines, blood pressure, and fasting plasma glucose and insulin. Results: The mean BMI in the subjects and controls was 28.7 and 28.2 kg/m2, respectively. Subjects had higher levels of plasma highsensitivity C-reactive protein (3.0 vs. 2.0 mg/liter; P < 0.001), lower levels of adiponectin (4.7 vs. 6.6 mg/liter; P < 0.001), and, after adjustment for age, BMI, gender, smoking, statin, and β-blocker use, higher systolic (P = 0.001) and diastolic (P = 0.05) blood pressures. Fasting plasma glucose, insulin, and homeostasis model of assessment-insulin resistance were all significantly higher in subjects than controls (P < 0.0001). Conclusions: Identification of people solely on the basis of an elevated plasma triglyceride and a low HDL-C uncovers an overweight group of people who have a generalized metabolic disorder. In contrast, overweight people with normal plasma lipids have normal glucose and insulin metabolism, low levels of inflammatory markers, and normal blood pressure. Such people may thus be at relatively low risk of developing diabetes and cardiovascular disease despite being overweight.

Original languageEnglish (US)
Pages (from-to)2041-2045
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number6
DOIs
StatePublished - Jun 2007

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Dyslipidemias
Insulin
Plasmas
Blood pressure
Body Mass Index
Serum
HDL Cholesterol
Triglycerides
Blood Pressure
Glucose
Fasting
Cardiovascular Diseases
Institutional Practice
Outcome Assessment (Health Care)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Adipokines
Adiponectin
Medical problems
Metabolism
C-Reactive Protein

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia. / Barter, Philip; McPherson, Y. Ruth; Song, Kijoung; Kesäniemi, Y. Antero; Mahley, Robert; Waeber, Gérard; Bersot, Thomas; Mooser, Vincent; Waterworth, Dawn; Grundy, Scott M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 6, 06.2007, p. 2041-2045.

Research output: Contribution to journalArticle

Barter, P, McPherson, YR, Song, K, Kesäniemi, YA, Mahley, R, Waeber, G, Bersot, T, Mooser, V, Waterworth, D & Grundy, SM 2007, 'Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia', Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2041-2045. https://doi.org/10.1210/jc.2006-2219
Barter, Philip ; McPherson, Y. Ruth ; Song, Kijoung ; Kesäniemi, Y. Antero ; Mahley, Robert ; Waeber, Gérard ; Bersot, Thomas ; Mooser, Vincent ; Waterworth, Dawn ; Grundy, Scott M. / Serum insulin and inflammatory markers in overweight individuals with and without dyslipidemia. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 6. pp. 2041-2045.
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abstract = "Context: The worldwide epidemic of overweight and obesity is setting the scene for a new wave of premature cardiovascular disease. Objective: The objective of this study was to define relationships between dyslipidemia and other metabolic abnormalities in overweight subjects. Design: This study included comparison of overweight subjects with and without dyslipidemia. Setting: The setting was an institutional practice. Patients: Dyslipidemic subjects (n = 715) had plasma triglyceride greater than or equal to the 75th percentile in combination with high-density lipoprotein cholesterol (HDL-C) less than or equal to the 25th percentile. Unrelated, normolipidemic controls (n = 1073) had HDL-C higher than the median and triglyceride lower than the median. It was a requirement for the control subjects to have a body mass index (BMI) greater than 25 kg/m2. Main Outcome Measures: The main outcome measures included BMI, inflammatory markers, adipokines, blood pressure, and fasting plasma glucose and insulin. Results: The mean BMI in the subjects and controls was 28.7 and 28.2 kg/m2, respectively. Subjects had higher levels of plasma highsensitivity C-reactive protein (3.0 vs. 2.0 mg/liter; P < 0.001), lower levels of adiponectin (4.7 vs. 6.6 mg/liter; P < 0.001), and, after adjustment for age, BMI, gender, smoking, statin, and β-blocker use, higher systolic (P = 0.001) and diastolic (P = 0.05) blood pressures. Fasting plasma glucose, insulin, and homeostasis model of assessment-insulin resistance were all significantly higher in subjects than controls (P < 0.0001). Conclusions: Identification of people solely on the basis of an elevated plasma triglyceride and a low HDL-C uncovers an overweight group of people who have a generalized metabolic disorder. In contrast, overweight people with normal plasma lipids have normal glucose and insulin metabolism, low levels of inflammatory markers, and normal blood pressure. Such people may thus be at relatively low risk of developing diabetes and cardiovascular disease despite being overweight.",
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AU - Barter, Philip

AU - McPherson, Y. Ruth

AU - Song, Kijoung

AU - Kesäniemi, Y. Antero

AU - Mahley, Robert

AU - Waeber, Gérard

AU - Bersot, Thomas

AU - Mooser, Vincent

AU - Waterworth, Dawn

AU - Grundy, Scott M

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N2 - Context: The worldwide epidemic of overweight and obesity is setting the scene for a new wave of premature cardiovascular disease. Objective: The objective of this study was to define relationships between dyslipidemia and other metabolic abnormalities in overweight subjects. Design: This study included comparison of overweight subjects with and without dyslipidemia. Setting: The setting was an institutional practice. Patients: Dyslipidemic subjects (n = 715) had plasma triglyceride greater than or equal to the 75th percentile in combination with high-density lipoprotein cholesterol (HDL-C) less than or equal to the 25th percentile. Unrelated, normolipidemic controls (n = 1073) had HDL-C higher than the median and triglyceride lower than the median. It was a requirement for the control subjects to have a body mass index (BMI) greater than 25 kg/m2. Main Outcome Measures: The main outcome measures included BMI, inflammatory markers, adipokines, blood pressure, and fasting plasma glucose and insulin. Results: The mean BMI in the subjects and controls was 28.7 and 28.2 kg/m2, respectively. Subjects had higher levels of plasma highsensitivity C-reactive protein (3.0 vs. 2.0 mg/liter; P < 0.001), lower levels of adiponectin (4.7 vs. 6.6 mg/liter; P < 0.001), and, after adjustment for age, BMI, gender, smoking, statin, and β-blocker use, higher systolic (P = 0.001) and diastolic (P = 0.05) blood pressures. Fasting plasma glucose, insulin, and homeostasis model of assessment-insulin resistance were all significantly higher in subjects than controls (P < 0.0001). Conclusions: Identification of people solely on the basis of an elevated plasma triglyceride and a low HDL-C uncovers an overweight group of people who have a generalized metabolic disorder. In contrast, overweight people with normal plasma lipids have normal glucose and insulin metabolism, low levels of inflammatory markers, and normal blood pressure. Such people may thus be at relatively low risk of developing diabetes and cardiovascular disease despite being overweight.

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