Serum Lactate Dehydrogenase and Bone Marrow Metastases in Small-Cell Carcinoma of the Lung

Kell Østerlind, Fred R. Hirsch, Anders G. Pedersen, David H. Johnson, F. Anthony Greco, Donald C. Doll

Research output: Contribution to journalLetter

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To the Editor: In a letter in the May 9 issue of the Journal Donald C. Doll1 suggests that bone marrow examination can be omitted in the staging of patients with small-cell lung cancer and normal serum lactate dehydrogenase levels. The suggestion was based on data from 95 patients. To elucidate the consequences of this suggestion, we reviewed data from 942 patients with small-cell lung cancer who were consecutively included in prospective trials conducted in Copenhagen between June 1976 and May 1984. Pretreatment serum lactate dehydrogenase activity was determined and bilateral bone marrow biopsy and aspiration2 were performed in 872.

Original languageEnglish (US)
Pages (from-to)759-760
Number of pages2
JournalNew England Journal of Medicine
Issue number12
Publication statusPublished - Sep 19 1985


ASJC Scopus subject areas

  • Medicine(all)

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