Serum levels of neurofilament-h are elevated in patients suffering from severe burns

Joshua W. Gatson, Ming Mei Liu, Fernando A. Rivera-Chavez, Joseph P. Minei, Steven E. Wolf

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In previous studies, after injury, burn patients experienced an increase in neuro-inflammation, edema, and neuronal cell death. As demonstrated in other brain injury models, fluid-based biomarkers such as phosphorylated neurofilament-H (pNFL-H) have been shown to correlate with injury severity. In this study the authors hypothesized that burn-injured patients have an increase in pNFL-H in the blood during the acute and chronic time-points after injury. In this prospective clinical study, blood (8 cc) was collected from burn patients (n = 36; TBSA 10-60%) at Parkland hospital, Dallas, Texas, on days 1, 7, and 14 after injury. The serum levels of pNFL-H were measured using the enzyme-linked immunoassay. Compared to noninjured controls, the burn patients exhibited a significant increase in the serum levels of pNFL-H on days 7 (P

Original languageEnglish (US)
Pages (from-to)545-550
Number of pages6
JournalJournal of Burn Care and Research
Volume36
Issue number5
DOIs
StatePublished - Oct 1 2015

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ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

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