Abstract
Rationale Neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) have been implicated in both the stress response and alcohol addiction. However, few studies have assessed the NPY and BDNF response to stress in alcoholdependent participants and the concurrent measure of NPY and BDNF has not been reported in human participants. Objective The purpose of this study was to concurrently assess serum NPYand BDNF, as well as adrenocorticotropin (ACTH) and cortisol, in control and race- and aged-matched abstinent alcohol-dependent participants in response to a stress-inducing public-speaking task. Methods Basal and post-stress serum values of NPY and BDNF, as well as ACTH and cortisol, were assessed in 14 abstinent alcohol-dependent and ten healthy control male participants. Results Basal measures were stable over short periods of time and stress induced a significant increase in both NPY (p= 0.002) and BDNF (p=0.006) as well as ACTH (p<0.001) and cortisol (p<0.007). Alcohol-dependent and control groups did not significantly differ on any basal or stressinduced measure. Basal and delta responses of NPY and BDNF were not significantly correlated, and delta peak responses of NPY and BDNF did not correlate with one another or with their respective ACTH and cortisol responses. Conclusions These findings reveal that both serum NPY and BDNF are responsive to behavioral stressors, although their regulatory mechanisms appear to differ from one another and those of the hypothalamic-pituitary-adrenal axis. Differences in basal and stress-induced responses of NPY and BDNF were not supported between control and abstinent alcohol-dependent subjects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-67 |
| Number of pages | 9 |
| Journal | Psychopharmacology |
| Volume | 218 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 2011 |
Fingerprint
Keywords
- Adrenocorticotropic hormone
- Alcoholism
- Brain-derived neurotrophic factor
- Cortisol
- Neuropeptide Y
- Psychological
- Stress
ASJC Scopus subject areas
- Pharmacology
Cite this
Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants. / Meng, Donna; Wu, TingChin; Rao, Uma; North, Carol S; Xiao, Hong; Javors, Martin A.; Adinoff, Bryon H.
In: Psychopharmacology, Vol. 218, No. 1, 11.2011, p. 59-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants
AU - Meng, Donna
AU - Wu, TingChin
AU - Rao, Uma
AU - North, Carol S
AU - Xiao, Hong
AU - Javors, Martin A.
AU - Adinoff, Bryon H
PY - 2011/11
Y1 - 2011/11
N2 - Rationale Neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) have been implicated in both the stress response and alcohol addiction. However, few studies have assessed the NPY and BDNF response to stress in alcoholdependent participants and the concurrent measure of NPY and BDNF has not been reported in human participants. Objective The purpose of this study was to concurrently assess serum NPYand BDNF, as well as adrenocorticotropin (ACTH) and cortisol, in control and race- and aged-matched abstinent alcohol-dependent participants in response to a stress-inducing public-speaking task. Methods Basal and post-stress serum values of NPY and BDNF, as well as ACTH and cortisol, were assessed in 14 abstinent alcohol-dependent and ten healthy control male participants. Results Basal measures were stable over short periods of time and stress induced a significant increase in both NPY (p= 0.002) and BDNF (p=0.006) as well as ACTH (p<0.001) and cortisol (p<0.007). Alcohol-dependent and control groups did not significantly differ on any basal or stressinduced measure. Basal and delta responses of NPY and BDNF were not significantly correlated, and delta peak responses of NPY and BDNF did not correlate with one another or with their respective ACTH and cortisol responses. Conclusions These findings reveal that both serum NPY and BDNF are responsive to behavioral stressors, although their regulatory mechanisms appear to differ from one another and those of the hypothalamic-pituitary-adrenal axis. Differences in basal and stress-induced responses of NPY and BDNF were not supported between control and abstinent alcohol-dependent subjects.
AB - Rationale Neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) have been implicated in both the stress response and alcohol addiction. However, few studies have assessed the NPY and BDNF response to stress in alcoholdependent participants and the concurrent measure of NPY and BDNF has not been reported in human participants. Objective The purpose of this study was to concurrently assess serum NPYand BDNF, as well as adrenocorticotropin (ACTH) and cortisol, in control and race- and aged-matched abstinent alcohol-dependent participants in response to a stress-inducing public-speaking task. Methods Basal and post-stress serum values of NPY and BDNF, as well as ACTH and cortisol, were assessed in 14 abstinent alcohol-dependent and ten healthy control male participants. Results Basal measures were stable over short periods of time and stress induced a significant increase in both NPY (p= 0.002) and BDNF (p=0.006) as well as ACTH (p<0.001) and cortisol (p<0.007). Alcohol-dependent and control groups did not significantly differ on any basal or stressinduced measure. Basal and delta responses of NPY and BDNF were not significantly correlated, and delta peak responses of NPY and BDNF did not correlate with one another or with their respective ACTH and cortisol responses. Conclusions These findings reveal that both serum NPY and BDNF are responsive to behavioral stressors, although their regulatory mechanisms appear to differ from one another and those of the hypothalamic-pituitary-adrenal axis. Differences in basal and stress-induced responses of NPY and BDNF were not supported between control and abstinent alcohol-dependent subjects.
KW - Adrenocorticotropic hormone
KW - Alcoholism
KW - Brain-derived neurotrophic factor
KW - Cortisol
KW - Neuropeptide Y
KW - Psychological
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=82955187778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955187778&partnerID=8YFLogxK
U2 - 10.1007/s00213-011-2414-1
DO - 10.1007/s00213-011-2414-1
M3 - Article
C2 - 21796371
AN - SCOPUS:82955187778
VL - 218
SP - 59
EP - 67
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 1
ER -