Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder

Sarika Singh, Umar Yazdani, Bharathi Gadad, Sayed Zaman, Linda S. Hynan, Nichole Roatch, Claire Schutte, C. Nathan Marti, Laura Hewitson, Dwight C. German

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay. Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76%, but using both proteins together, the diagnostic accuracy increased to 82%. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores. Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.

Original languageEnglish (US)
Article number113
JournalJournal of Neuroinflammation
Volume14
Issue number1
DOIs
StatePublished - Jun 2 2017

Fingerprint

Thyrotropin
Interleukin-8
Serum
Proteins
Biomarkers
Autism Spectrum Disorder
Autistic Disorder
Immunoassay
Early Diagnosis
Appointments and Schedules
Observation

Keywords

  • Autism
  • Biomarker
  • Serum proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder. / Singh, Sarika; Yazdani, Umar; Gadad, Bharathi; Zaman, Sayed; Hynan, Linda S.; Roatch, Nichole; Schutte, Claire; Marti, C. Nathan; Hewitson, Laura; German, Dwight C.

In: Journal of Neuroinflammation, Vol. 14, No. 1, 113, 02.06.2017.

Research output: Contribution to journalArticle

Singh, Sarika ; Yazdani, Umar ; Gadad, Bharathi ; Zaman, Sayed ; Hynan, Linda S. ; Roatch, Nichole ; Schutte, Claire ; Marti, C. Nathan ; Hewitson, Laura ; German, Dwight C. / Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder. In: Journal of Neuroinflammation. 2017 ; Vol. 14, No. 1.
@article{12b7963f27a246e3a3fbaaabb34f30f8,
title = "Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder",
abstract = "Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay. Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76{\%}, but using both proteins together, the diagnostic accuracy increased to 82{\%}. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores. Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.",
keywords = "Autism, Biomarker, Serum proteins",
author = "Sarika Singh and Umar Yazdani and Bharathi Gadad and Sayed Zaman and Hynan, {Linda S.} and Nichole Roatch and Claire Schutte and Marti, {C. Nathan} and Laura Hewitson and German, {Dwight C.}",
year = "2017",
month = "6",
day = "2",
doi = "10.1186/s12974-017-0888-4",
language = "English (US)",
volume = "14",
journal = "Journal of Neuroinflammation",
issn = "1742-2094",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder

AU - Singh, Sarika

AU - Yazdani, Umar

AU - Gadad, Bharathi

AU - Zaman, Sayed

AU - Hynan, Linda S.

AU - Roatch, Nichole

AU - Schutte, Claire

AU - Marti, C. Nathan

AU - Hewitson, Laura

AU - German, Dwight C.

PY - 2017/6/2

Y1 - 2017/6/2

N2 - Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay. Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76%, but using both proteins together, the diagnostic accuracy increased to 82%. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores. Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.

AB - Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay. Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76%, but using both proteins together, the diagnostic accuracy increased to 82%. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores. Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.

KW - Autism

KW - Biomarker

KW - Serum proteins

UR - http://www.scopus.com/inward/record.url?scp=85020030798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020030798&partnerID=8YFLogxK

U2 - 10.1186/s12974-017-0888-4

DO - 10.1186/s12974-017-0888-4

M3 - Article

C2 - 28577577

AN - SCOPUS:85020030798

VL - 14

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

SN - 1742-2094

IS - 1

M1 - 113

ER -