Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder

Sarika Singh, Umar Yazdani, Bharathi Gadad, Sayed Zaman, Linda S. Hynan, Nichole Roatch, Claire Schutte, C. Nathan Marti, Laura Hewitson, Dwight C. German

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay. Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76%, but using both proteins together, the diagnostic accuracy increased to 82%. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores. Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.

Original languageEnglish (US)
Article number113
JournalJournal of Neuroinflammation
Volume14
Issue number1
DOIs
StatePublished - Jun 2 2017

Keywords

  • Autism
  • Biomarker
  • Serum proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

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