TY - JOUR
T1 - Serum zinc and its relation to bone mineral density in β-thalassemic adolescents
AU - Bekheirnia, Mir Reza
AU - Shamshirsaz, Alireza Abdollah
AU - Kamgar, Mohammad
AU - Bouzari, Navid
AU - Erfanzadeh, Ghazaleh
AU - Pourzahedgilani, Nima
AU - Tabatabaie, Seyed Mahmood
AU - Shamshirsaz, Amirhooshang Abdollah
AU - Kimiagar, Masood
AU - Ezzati, Fatemeh
AU - Larijani, Bagher
N1 - Funding Information:
This study was funded by Charity Foundation for Special Diseases. The authors wish to thank all thalassemic participants; and the clinical laboratory of the Endocrinology and Metabolism Research Centre at Shariati Hospital, and the biochemical laboratory of Tarbiat Modarres University, who performed the laboratory assays.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2004/3
Y1 - 2004/3
N2 - Trace elements have been considered to play critical roles in bone metabolism. This study aims at determining the serum zinc profile and its association with bone mineral density (BMD) abnormalities in thalassemic patients. In 131 transfusion-dependent β-thalassemic patients, aged 10-20 yr, serum levels of zinc were measured by flame atomic absorption spectrophotometry (F-AAS). BMD values at the lumbar (L1-L4) and femoral neck were determined by dual X-ray absorptiometry (DXA). Dietary zinc intake and daily consumption of calcium were evaluated by a food-frequency questionnaire. Low serum zinc was found in 84.8% (in 44.7% severely low). Below -2 BMD Z-scores were observed in 68.7% and 17.6% of the patients at the lumbar and femoral regions, respectively. Female patients with severe zinc deficiency had lower lumbar BMD Z-scores in comparison to the other females (-3.26 vs -2.54). Serum zinc in females with femoral BMD Z-scores < - 2 was significantly lower by 16.4 μg/dL than other females. Our study suggests that serum levels of zinc can be lowered in the thalassemic patients and partly affect the BMD.
AB - Trace elements have been considered to play critical roles in bone metabolism. This study aims at determining the serum zinc profile and its association with bone mineral density (BMD) abnormalities in thalassemic patients. In 131 transfusion-dependent β-thalassemic patients, aged 10-20 yr, serum levels of zinc were measured by flame atomic absorption spectrophotometry (F-AAS). BMD values at the lumbar (L1-L4) and femoral neck were determined by dual X-ray absorptiometry (DXA). Dietary zinc intake and daily consumption of calcium were evaluated by a food-frequency questionnaire. Low serum zinc was found in 84.8% (in 44.7% severely low). Below -2 BMD Z-scores were observed in 68.7% and 17.6% of the patients at the lumbar and femoral regions, respectively. Female patients with severe zinc deficiency had lower lumbar BMD Z-scores in comparison to the other females (-3.26 vs -2.54). Serum zinc in females with femoral BMD Z-scores < - 2 was significantly lower by 16.4 μg/dL than other females. Our study suggests that serum levels of zinc can be lowered in the thalassemic patients and partly affect the BMD.
KW - Bone mineral density
KW - Dietary zinc intake
KW - Osteoporosis
KW - Serum zinc
KW - Thalassemia
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U2 - 10.1385/BTER:97:3:215
DO - 10.1385/BTER:97:3:215
M3 - Article
C2 - 14997022
AN - SCOPUS:12144287429
SN - 0163-4984
VL - 97
SP - 215
EP - 224
JO - Biological Trace Element Research
JF - Biological Trace Element Research
IS - 3
ER -