Severe intraventricular hemorrhage and withdrawal of support in preterm infants

J. W. Sheehan, M. Pritchard, R. J. Heyne, L. S. Brown, M. A. Jaleel, W. D. Engle, P. J. Burchfield, L. P. Brion

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective:The objective of the study was to determine whether withdrawal of support in severe ‘intraventricular hemorrhage’ (IVH), that is, IVH grade 3 and periventricular hemorrhagic infarction (PVHI), has decreased after publication of studies that show improved prognosis and to examine cranial ultrasonograms, including PVHI territories defined by Bassan.Study Design:Retrospective cohort of preterm infants from 23 0/7 to 28 6/7 weeks’ gestation in 1993 to 2013.Results:Among the 1755 infants, 1494 had no bleed, germinal matrix hemorrhage (GMH) or IVH grade 2, 137 had grade 3 IVH and 124 had PVHI. The odds of withdrawal of support, adjusted for severity of GMH-IVH and baseline variables, did not decrease after publications showing better prognosis. Among 82 patients who died with PVHI, 76 had life support withdrawn, including 34 without another contributing cause of death. The median number of PVHI territories involved was three.Conclusion:Withdrawal of support adjusted for severity of GMH-IVH did not significantly change after publications showing better prognosis.Journal of Perinatology advance online publication, 15 December 2016; doi:10.1038/jp.2016.233.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Dec 15 2016

Fingerprint

Premature Infants
Hemorrhage
Infarction
Publications
Perinatology
Cause of Death
Retrospective Studies
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Severe intraventricular hemorrhage and withdrawal of support in preterm infants. / Sheehan, J. W.; Pritchard, M.; Heyne, R. J.; Brown, L. S.; Jaleel, M. A.; Engle, W. D.; Burchfield, P. J.; Brion, L. P.

In: Journal of Perinatology, 15.12.2016.

Research output: Contribution to journalArticle

@article{da7a0517dd694b0b856c1863ddcaccd5,
title = "Severe intraventricular hemorrhage and withdrawal of support in preterm infants",
abstract = "Objective:The objective of the study was to determine whether withdrawal of support in severe ‘intraventricular hemorrhage’ (IVH), that is, IVH grade 3 and periventricular hemorrhagic infarction (PVHI), has decreased after publication of studies that show improved prognosis and to examine cranial ultrasonograms, including PVHI territories defined by Bassan.Study Design:Retrospective cohort of preterm infants from 23 0/7 to 28 6/7 weeks’ gestation in 1993 to 2013.Results:Among the 1755 infants, 1494 had no bleed, germinal matrix hemorrhage (GMH) or IVH grade 2, 137 had grade 3 IVH and 124 had PVHI. The odds of withdrawal of support, adjusted for severity of GMH-IVH and baseline variables, did not decrease after publications showing better prognosis. Among 82 patients who died with PVHI, 76 had life support withdrawn, including 34 without another contributing cause of death. The median number of PVHI territories involved was three.Conclusion:Withdrawal of support adjusted for severity of GMH-IVH did not significantly change after publications showing better prognosis.Journal of Perinatology advance online publication, 15 December 2016; doi:10.1038/jp.2016.233.",
author = "Sheehan, {J. W.} and M. Pritchard and Heyne, {R. J.} and Brown, {L. S.} and Jaleel, {M. A.} and Engle, {W. D.} and Burchfield, {P. J.} and Brion, {L. P.}",
year = "2016",
month = "12",
day = "15",
doi = "10.1038/jp.2016.233",
language = "English (US)",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Severe intraventricular hemorrhage and withdrawal of support in preterm infants

AU - Sheehan, J. W.

AU - Pritchard, M.

AU - Heyne, R. J.

AU - Brown, L. S.

AU - Jaleel, M. A.

AU - Engle, W. D.

AU - Burchfield, P. J.

AU - Brion, L. P.

PY - 2016/12/15

Y1 - 2016/12/15

N2 - Objective:The objective of the study was to determine whether withdrawal of support in severe ‘intraventricular hemorrhage’ (IVH), that is, IVH grade 3 and periventricular hemorrhagic infarction (PVHI), has decreased after publication of studies that show improved prognosis and to examine cranial ultrasonograms, including PVHI territories defined by Bassan.Study Design:Retrospective cohort of preterm infants from 23 0/7 to 28 6/7 weeks’ gestation in 1993 to 2013.Results:Among the 1755 infants, 1494 had no bleed, germinal matrix hemorrhage (GMH) or IVH grade 2, 137 had grade 3 IVH and 124 had PVHI. The odds of withdrawal of support, adjusted for severity of GMH-IVH and baseline variables, did not decrease after publications showing better prognosis. Among 82 patients who died with PVHI, 76 had life support withdrawn, including 34 without another contributing cause of death. The median number of PVHI territories involved was three.Conclusion:Withdrawal of support adjusted for severity of GMH-IVH did not significantly change after publications showing better prognosis.Journal of Perinatology advance online publication, 15 December 2016; doi:10.1038/jp.2016.233.

AB - Objective:The objective of the study was to determine whether withdrawal of support in severe ‘intraventricular hemorrhage’ (IVH), that is, IVH grade 3 and periventricular hemorrhagic infarction (PVHI), has decreased after publication of studies that show improved prognosis and to examine cranial ultrasonograms, including PVHI territories defined by Bassan.Study Design:Retrospective cohort of preterm infants from 23 0/7 to 28 6/7 weeks’ gestation in 1993 to 2013.Results:Among the 1755 infants, 1494 had no bleed, germinal matrix hemorrhage (GMH) or IVH grade 2, 137 had grade 3 IVH and 124 had PVHI. The odds of withdrawal of support, adjusted for severity of GMH-IVH and baseline variables, did not decrease after publications showing better prognosis. Among 82 patients who died with PVHI, 76 had life support withdrawn, including 34 without another contributing cause of death. The median number of PVHI territories involved was three.Conclusion:Withdrawal of support adjusted for severity of GMH-IVH did not significantly change after publications showing better prognosis.Journal of Perinatology advance online publication, 15 December 2016; doi:10.1038/jp.2016.233.

UR - http://www.scopus.com/inward/record.url?scp=85006289226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006289226&partnerID=8YFLogxK

U2 - 10.1038/jp.2016.233

DO - 10.1038/jp.2016.233

M3 - Article

C2 - 27977011

AN - SCOPUS:85006289226

JO - Journal of Perinatology

JF - Journal of Perinatology

SN - 0743-8346

ER -